TAILIEUCHUNG - Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 24)

Introduction: Lysergic acid diethylamide (LSD, lysergide) is known as one of the most powerful hallucinogenic drugs of abuse. LSD was explosively abused in . in the latter half of the 1960s. In Japan, the amount of seizure of LSD is much smaller than that of methamphetamine. However, in recent years, it has been increasing markedly; 3,500 tablets of LSD were seized in 1996, while 53,043 tablets in 2000 (about 15-fold increase), arousing a serious concern about the phenomenon. LSD is a compound chemically modified from ergot alkaloid produced by a bacterium Claviceps purpurea. LSD is one of the compounds synthesized. | Lysergic acid diethylamide LSD by Shinichi Suzuki Introduction Lysergic acid diethylamide LSD lysergide is known as one of the most powerful hallucinogenic drugs of abuse. LSD was explosively abused in . in the latter half of the 1960s. In Japan the amount of seizure of LSD is much smaller than that of methamphetamine. However in recent years it has been increasing markedly 3 500 tablets of LSD were seized in 1996 while 53 043 tablets in 2000 about 15-fold increase arousing a serious concern about the phenomenon. LSD is a compound chemically modified from ergot alkaloid produced by a bacterium Claviceps purpurea. LSD is one of the compounds synthesized by the reactions of lysergic acid isolated from the ergot with various amines at the Rockefeller Institute in the 1930s LSD was synthesized as the 25th compound and thus called LSD-25. The strong hallucinogenic activity of LSD was confirmed by Albert Hofmann who did synthesize the compound the pharmacological activity can be obtained by oral administration of as small as 20-75 pg of LSD. The absorption of LSD from the digestive tract is rapid and distinct visual hallucination takes place 45 min-1 h after oral intake of about 20 pg of LSD 1 . The hallucination becomes most marked 2-3 h after the intake and lasts for 8-12 h. In this chapter a detection method by TLC and confirmatory analysis by GC MS for LSD are presented. Reagents and their preparation LSD can be obtained from each local bureau of drug enforcement officers under an official transfer process. p-Dimethylbenzaldehyde reagent a aliquot of p-dimethylaminobenzaldehyde Wako Pure Chemical Industries Ltd. Osaka Japan and other manufacturers is dissolved in 100 mL of 65 sulfuric acid solution followed by the addition of mL of 5 ferric chloride aqueous solution. Dragendorff reagent 2 there are various modifications of its preparation the most typical method is described here. A aliquot of bismuth subnitrate is dissolved in a .

• Y học thường thức
• Drugs and Poisons in Humans
• Handbook of Practical Analysis
• tác hại của ma tuý
• chất độc hại cho con người
• phòng chống nghiện ma tuý
• Lysergic acid diethylamide
• computer system for diagnosis
• causative drugs
• poisons developed
• Alternative specimens
• Pretreatments of human specimens
• Detection methods
• Practical use
• the poison net developed
• Problems in toxin analysis
• emergency medicine
• Analysis of chemical warfare agents
• related compounds
• Carbon monoxide
• Hydrogen sulfide
• metabolite
• Cyanide
• Methanol and formic acid
• Ethanol
• Chloroform and dichloromethane
• Toluene
• benzene
• xylene
• styrene
• Alkyl nitrites
• Components of gasoline
• Amphetamines
• metabolites
• Cannabinoids
• Morphine and its analogues
• Cocaine and its metabolites
• Pentazocine
• Methylenedioxyamphetamines