TAILIEUCHUNG - Flavonoids from Alpinia vietnamica, and their cytotoxic, antioxidative, and α-glucosidase inhibitory activities

Alpinia vietnamica . Tran, Luu & Skornick was identified as a new species in 2019, which is widely distributed in Thua Thien Hue, Quang Nam, and Kon Tum provinces, Vietnam. The current study wishes to report phytochemical investigation, and the biological activities (cytotoxic, antioxidative, and α-glucosidase inhibitory) of isolated compounds. | Received 25 May 2023 Revised 7 August 2023 Accepted 14 August 2023 DOI RESEARCH ARTICLE Flavonoids from Alpinia vietnamica and their cytotoxic antioxidative and α-glucosidase inhibitory activities Nguyen Thanh Tra1 2 Nguyen Thi Thuy Hoa2 Nguyen Thi Thuy Linh1 Nguyen Thi Thu Ha1 2 Ba Thi Cham1 Le Thi Tu Anh1 Ninh The Son1 2 1 Institute of Chemistry Vietnam Academy Science and Technology VAST Cau Giay Hanoi Abstract Vietnam Phytochemical research of the 80 EtOH whole plant extract of Alpinia 2 Graduate University of Science and Technology vietnamica . Tran Luu amp Skornick resulted in the isolation and structural Vietnam Academy Science and Technology elucidation of seven compounds 1 7 including two flavones quercetin-3-O- VAST Cau Giay Hanoi Vietnam α-L-rhamnosyl 1 2 -α-L-rhamnoside 1 and diosmetin 2 three flavanones Correspondence pinocembrin 3 alpinetin 4 and 5-O-methylnaringenin 5 and two chalcones Ninh The Son Institute of Chemistry Vietnam cardamonin 6 and helichrysetin 7 . The isolated compounds have shown bio- Academy Science and Technology VAST 18 logical effects at different levels. Two chalcones 6 7 showed cytotoxicity toward Hoang Quoc Viet Cau Giay Hanoi 10000 Vietnam. four cancer cell lines KB MCF7 A549 and HepG2 especially compound 7 strongly Email ntson@ inhibited the growth of A549 cancerous cells with the IC50 of μM. Flavone 1 strongly exhibited antioxidative activity to scavenge DPPH radicals with the IC50 of Funding information μM. Flavone 2 and flavanone 4 moderately inhibited enzyme α-glucosidase Vietnam Academy Science and Technology with the IC50 values of μM. Grant Award Number 22-23 KEYWORDS Alpinia vietnamica antioxidant cytotoxicity flavonoids rhizome α-glucosidase inhibitory 1 INTRODUCTION The current study wishes to report phytochem- ical investigation and the biological activities cytotoxic Alpinia is a genus of 230 flowering plants in the ginger .

• Sinh học
• Single nucleotide variants
• α glucosidase inhibitory
• Alpinia vietnamica
• Report phytochemical investigation
• Chalcones cardamonin
• BMC Genomics
• Individual animal genotype
• Concordance rate
• Single nucleotide polymorphism haplotypes
• Medium density
• BMC Cancer
• Breast cancer
• Single nucleotide variation
• Copy number variation
• Summary receiver operative curve
• Next generation sequencing
• Genomic exploration
• Reveal gene mutations
• Mapping quality
• Single cell genomics
• Cancer evolution
• Acute lymphoblastic leukemia
• Single cancer cells
• BMC Bioinformatics
• Somatic single nucleotide variants
• Whole exome sequencing
• Detecting somatic mutations
• Acute lymphoblastic leukemias
• Complex disease
• High throughput sequencing
• SNV frequency measurements
• Log R ratio
• Holstein Friesian
• Fluorescence intensity
• Single nucleotide polymorphisms
• Genome Biology
• Single nucleotide polymorphism
• RNA splicing
• Computational biology
• Disease pathogenesis
• Random forest
• Prediction model
• BMC Veterinary Research
• Antibody response
• Single nucleotide variant
• Salmonella enterica serovars
• Foodborne illness
• Alternative control methods
• Structural variation
• Underlying models
• Tissue specific regulatory network
• Cancer drivers
• Structural variants
• DNA methylation
• Prostate cancer
• Nucleotide variants
• Synonymous single nucleotide polymorphisms
• Protein translation
• Cystic fibrosis
• Fucosyltransferase 2
• Hepatocellular carcinoma
• Tumor progression
• FUT2 genetic variants
• báo cáo khoa học
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• công trình nghiên cứu về y học
• tài liệu về y học
• cách trình bày báo cáo
• Colorectal cancer
• Small non coding RNA
• Influence sncRNA function
• hsa miR 196a
• Mitotic cell cycle
• Major depressive disorder
• Single nucleotide polymorphisms rs6264
• Del polymorphism of ACE
• Recurrent depressive disorder
• East Slavic population
• BMC Plant Biology
• Ambient temperature signaling
• Arabidopsis thaliana
• Quantitative trait locus
• DNA repair gene
• Toxicity during chemotherapy
• Gene environment interaction
• Smoking behaviors
• Case control study
• Polygenic risk
• Genomic testing
• Genetic counselling
• Behavioral outcomes
• Driver genes
• Genetic susceptibility
• Cancer susceptibility
• Genetic associations
• Oxidative stress
• Oxygen metabolism
• Antioxidant genes
• Cis regulatory elements
• Transcriptional regulation
• Disease development
• Mutational signatures
• COSMIC database
• Cancer genomics
• Web tool