TAILIEUCHUNG - Summary of Biology doctoral thesis: Study on mutations, expression of EGFR and methylation of related genes in lung adenocarcinoma patients

Analysis of mutation and protein expression of EGFR in patients with lung adenocarcinoma; investigation the hypermethylation frequency of EGFR, BRCA1, MGMT, MLH1, RASSF1A and correlation of the methylation between these genes with mutations and protein expression of EGFR. | MINISTRY OF EDUCATION VIETNAM ACADEMY AND TRAINING OF SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY SCIENCE AND TECHNOLOGY ---------------------------- NGUYEN NGOC QUANG STUDY ON MUTATION PROTEIN EXPRESSION OF EGFR AND METHYLATION OF RELATED GENES IN LUNG ADENOCARCINOMA PATIENTS Major Biotechnology Code 942 02 01 SUMMARY OF BIOLOGY DOCTORAL THESIS Hanoi - 2020 The research was completed at Graduate University Science and Technology Vietnam Academy of Science and Technology Supervisor 1 Assoc. Prof. Chu Hoang Ha Supervisor 2 PhD. MD. Nguyen Phi Hung Reviewer 1 Reviewer 2 Reviewer 3 . The thesis will be defended in front of the Academy Thesis Evaluation Council at graduate university science and technology vietnam academy of science and technology at date month year. The thesis can be found at - Graduate university science and technology library - Vietnam National library OBJECTIVES Lung cancer is the leading cause of cancer mortality in many countries. The activating mutations in the tyrosine kinase TK domain of epidermal growth factor receptor EGFR are considered as a therapeutic target for lung cancer. Targeted treatment regimen by tyrosine kinase inhibitors based on EGFR mutations have been widely used and contributed to improve clinical management. On other hand EGFR protein expression is controlled by methylation level of it promoter. Along with EGFR aberrant epigenetic alterations of tumor suppressor genes such as BRCA1 MGMT MLH1 RASSF1A are associated with the initiation and development of non-small cell lung cancer. The EGFR mutation has been reported in lung cancer partients in many recent studies. However the molecular alterations of EGFR and the effect of methylation of tumor suppressor genes on these changes are not comprehensively investigated. Therefore the goal of this PhD research was aimed to investigate quot Study on mutations expression of EGFR and methylation of related genes in lung adenocarcinoma patients quot . Objectives 1. Analysis of mutation

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