TAILIEUCHUNG - Isolation and structural determination of some chemical constituents from andrographis paniculata nees (acanthaceae) growing in Hung Yen province

From the ethanol extract of dried powders of Andrographis paniculata Nees leaves growing in Hung Yen Province, five compounds were isolated and identified: Andrographolide, dodecahexanoic acid, B-sitosterol, a mixture of 14-deoxy-11,12-didehydroandrographolide and 14-deoxyandrographolide (in ratio of 11:5). | JOURNAL OF SCIENCE OF HNUE 2011 Vol. 56 N . 1 pp. 27-33 ISOLATION AND STRUCTURAL DETERMINATION OF SOME CHEMICAL CONSTITUENTS FROM Andrographis paniculata NEES ACANTHACEAE GROWING IN HUNG YEN PROVINCE Pham Huu Dien and Hoang Thi Hoa Hanoi National University of Education E-mail dienhp@ Abstract. From the ethanol extract of dried powders of Andrographis pan- iculata Nees leaves growing in Hung Yen Province five compounds were isolated and identified andrographolide 1 dodecahexanoic acid 2 β- sitosterol 3 a mixture of 14-deoxy-11 12-didehydroandrographolide 4a and 14-deoxyandrographolide 4b in ratio of 11 5 . Their structures were confirmed by various spectral methods IR NMR EIMS 1 H-NMR 13 C- NMR etc. and by comparison with those of references. Keywords Andrographis paniculata Nees andrographolide dodeca- hexanoic acid β-sitosterol 14-deoxy-11 12-didehydroandrographolide 14- deoxyandrographolide isolation. 1. Introduction Xuyen Tam Lien is the Vietnamese name of the Andrographis paniculata Nees Acanthaceae plant which is wildely cultivated in Southern Asia including Viet- nam. Mostly the leaves and the roots have been traditionally used over the centuries for different medicinal purposes as a folklore remedy for a wide spectrum of ailments such as fever common colds hepatitis diabetes etc. 1 . Recent research on An- drographis paniculata Nees revealed that the plants have very large pharmacological effects such as anti-inflammation 2 anti-diarrhoea 3 antivirus 4 anti-malaria 5 anti-cancer 6 etc. Numerous studies have shown that bioactive constituents from Andrographis paniculata Nees are diterpenes diterpene lactones and its glycosides such as andro- grapholide panniculitis A-C 2 3 . In this paper we report our investigation on some chemical constituents of Andrographis paniculata Nees widely growing in Hung Yen Province. 27 Pham Huu Dien and Hoang Thi Hoa 2. Content . Experiments General experimental procedures IR spectra were recorded on SHIMADZU-FTIR

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• Dodecahexanoic acid
• 14 deoxy 11 12 didehydroandrographolide
• 14 deoxyandrographolide
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