TAILIEUCHUNG - A cytotoxic stilbenoid and 4-hydroxycinnamates from stemona cochinchinensis plants, growing in savannakhet province, lao PDR

Four non-alkaloidal metabolites: Stemanthrene C, methyl ferulate, methyl 4-hydroxycinnamate and B-sitosterol were isolated from the roots of Stemona cochinchinensis plants which were collected in Savannakhet Province (Laos). Their structures were elucidated by spectroscopic analyses. Stemanthrene C exhibited medium cytotoxic activity against the KB cell line with an IC50 value of ug mL−1. | JOURNAL OF SCIENCE OF HNUE Chemical and Biological Sci. 2012 Vol. 57 No. 8 pp. 9-15 This paper is available online at http A CYTOTOXIC STILBENOID AND 4-HYDROXYCINNAMATES FROM Stemona cochinchinensis PLANTS GROWING IN SAVANNAKHET PROVINCE LAO PDR Vonganatha Khamko1 2 Dang Ngoc Quang1 and Pham Huu Dien1 1 Faculty of Chemistry Hanoi National University of Education 2 Faculty of Chemistry Savannakhet University Savannakhet Province Lao PDR Abstract. Four non-alkaloidal metabolites stemanthrene C methyl ferulate methyl 4-hydroxycinnamate and β-sitosterol were isolated from the roots of Stemona cochinchinensis plants which were collected in Savannakhet Province Laos . Their structures were elucidated by spectroscopic analyses. Stemanthrene C exhibited medium cytotoxic activity against the KB cell line with an IC50 value of µg mL 1 . Keywords Stemona cochinchinensis stemanthrene C methyl 4-hydroxycinnamate methyl ferulate cytotoxic activity. 1. Introduction Various species of the genus Stemona Stemonaceae are widely used in Vietnam Laos and other countries of Southeast Asia as an anti-cough remedy and for their antiparasitic properties. Specifically extracts made from the tuberous roots of Lour. Gagnep. and have been used in Vietnamese and Laotian traditional medicine in a broad range of applications including relief of cough and asthma and reduction of enteric helminths and ectoparasites in humans and cattle 1-4 . Chemical investigations of Stemona genus species have resulted in the isolation of more than 90 different alkaloids most of which share the common pyrrolo 1 2-a azepine basic nucleus a minor fraction also containing the pyrido 1 2-a azepine skeleton 5-7 . However ofthe non-alkaloid components of this genus less than 20 compounds mostly of the dihydrophenanthrenes and dihydrostibenes have been investigated 8 9 . Herein Received May 25 2012. Accepted October 1 2012. Chemistry Subject Classification .

• Hoá học
• Stemona cochinchinensis
• Stemanthrene C
• Methyl 4 hydroxycinnamate
• Methyl ferulate
• Cytotoxic activity
• Bài viết nghiên cứu khoa học
• Nghiên cứu khoa học sinh viên
• Stemona tuberosa
• Dissertation summary organic chemistry
• The synthesis of cytotoxic activity of quinazoline compounds
• Evaluation of cytotoxic activity of quinazoline compounds
• Azides via triazole bridges
• Quinazoline derivative structure
• Amesiodendron chinense
• Leaves of amesiodendron chinense
• Weak cytotoxic activity
• NMR spectroscopic data
• Trigonostemon honbaensis
• Their cytotoxic activity
• Phenolic compounds
• Reference compounds
• Leaf extract
• Medicinal plants
• Cell lines
• Leaf extracts of selected medicinal plants
• In vitro cytotoxic activity
• Summary of doctoral thesis
• Summary of doctoral thesis on Chemistry
• Squirrel squirrel chemical composition
• Squirrel cytotoxic activity
• Glochidion Glomerulatum
• Squirrel squirrel species
• Glochidion Hirsutum
• Evaluation of toxic activity cells
• BMC Chemistry
• Lung cancer
• Human cancer cell lines
• Potential cytotoxic agents
• Green cabbage
• Sulforaphane composition
• Cytotoxic and antioxidant activity
• Crucifer vegetables
• Antioxidant activity
• Tamarix dioica
• In vitro antimicrobial
• Antifungal drugs
• Botanical origin
• Vietnam Journal of Science and Technology
• The new complex of Pt
• Characterization and cytotoxic activity
• The molecular formula
• Camphor 4 methyl thiosemicarbazone
• Structure elucidation and cytotoxic activity of attenuatoside
• Attenuatoside B 1 planciside A
• The starfish acanthaster planci
• Cytotoxicity against five human cancer
• Journal of Science and Technology
• Synthesis and cytotoxic activity evaluation
• Novel derivatives of murrayafoline a
• Natural carbazole alkaloids
• Two new conjugates of murrayafoline
• Journal of Biotechnology
• Chemical composition and cytotoxic activity
• The essential oils of cymbopogon citratus L
• grown
• Phu Tho province
• The natural sources of anticancer agents
• Ceratonia siliqua L
• Antimicrobial activity
• Shrimp lethality bioassay
• Pseudomonas aeroginosa
• The cytotoxic activity of extracts
• Fruiting bodies and mycelial biomass of cordyceps neovolkiana fungus
• Fungus against human Jurkat
• Biomass and fruit body extracts
• In vitro antiproliferative
• C6 cell line
• HeLa cell line
• HT29 cell line
• Human colon carcinoma
• Docinya indica
• Triterpene acids
• Cancer cell lines
• Euscaphic acid
• Thesis summary
• Summary of doctoral thesis Chemistry
• Starfish chemical composition
• Cytotoxic activity of starfish
• Culcita Novaeguineae Müller
• Starfish Pentaceraster Gracilis
• Study on chemical constituents
• Cytotoxic activity of 3 species allophylus livescens gagnep
• Chirita halongensis kiew
• T
• nguyen and oldenlandia pinifolia kuntze]
• Millettia pachyloba
• The stems of Millettia pachyloba
• Drake mediate cytotoxic activity
• Autophagy in cancer cells
• Flavonoids from the stems
• New quinazolinone derivatives
• 6 Hydroxy 4(3H) quinazolinone
• High yield
• Spectroscopic methods
• 5 Chloro 2 hydroxybenzohydrazide
• 2 hydroxy 5 iodobenzohydrazide
• N substituted hydrazide
• Cytotoxic activity against liver cancer cell
• Natural sciences
• Luận án Tiến sĩ
• Summary of Chemistry doctoral thesis
• Organic chemistry
• Actynomycetes strains Streptomyces G246
• East Vietnam sea
• Pouzolzia sanguinea
• Neolignans from Pouzolzia sanguinea
• Isolation of lignans
• HT93A acute leukemic cell lines
• Summary of dissertation on Doctor
• Philosophy in chemistry
• Anodendron paniculatum
• Natural sciences and Technology
• Cyanobacterial strains isolated
• Water pollution
• Water pollution treatment