TAILIEUCHUNG - Jak-Stat signaling pathway related gene expressions and blood biochemical indicators in acute promyelocytic leukemia

The results of this study would partially contribute to an understanding of the differences in JAK-STAT signaling associated gene expressions between APL and other leukemia groups. This is important to apply for effective chemotherapy for each type of leukemia. | VNU Journal of Science Medical and Pharmaceutical Sciences Vol. 36 No. 1 2020 75-83 Original Article Jak-Stat Signaling Pathway Related Gene Expressions and Blood Biochemical indicators in Acute Promyelocytic Leukemia Bui Kieu Trang1 Nguyen Thi Xuan1 2 1 Institute of Genome Research Vietnam Academy of Science and Technology A17 Building 18 Hoang Quoc Viet Cau Giay Hanoi Vietnam 2 Graduate University of Science and Technology Vietnam Academy of Science and Technology A28 Building 18 Hoang Quoc Viet Cau Giay Hanoi Vietnam Received 12 December 2019 Revised 25 February 2020 Accepted 20 March 2020 Abstract Acute promyelocytic leukemia APL is a type of acute leukemia which has the highest death rate among blood cancers and caused by a specific 15 17 chromosomal translocation resulting in a fusion gene PML RARα. Klotho gene plays a role in preventing aging inflammation and cancer. CTLA4 PD1 and LAG3 are immunosuppressive receptors located on surface of T cells and considered as a negative regulation of immune response. These genes regulate immune cell activity through several signalling moleculars such as STATs and NF-κB. In this study to additionally determine the difference between APL and other leukemia we performed experiments to measure mRNA expression of above genes by using realtime-PCR. Results showed that mRNA levels of KL CTLA4 PD1 and LAG3 genes were lower while expressions of STAT1 STAT3 STAT5 and STAT6 genes were significantly higher in APL patients than healthy controls. In addition IκB-α gene expression was unaltered on APL cells. The results of this study would partially contribute to an understanding of the differences in JAK-STAT signaling associated gene expressions between APL and other leukemia groups. This is important to apply for effective chemotherapy for each type of leukemia. Keywords Acute promyelocytic leukemia klotho CTLA4 IκB-α LAG3 PD1 STAT. ________ Corresponding author. E-mail address xuannt@ https 2588-1132 .

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