TAILIEUCHUNG - Etiology, antibiogram and quantitative endotracheal aspirate cultures in ventilator associated pneumonia patients in a Tertiary care hospital

Ventilator associated Pneumonia (VAP) is the second most common nosocomial infection in hospitals. Timely diagnosis and appropriate treatment will greatly decrease the mortality and morbidity. To potentially improve the specificity of the diagnosis of VAP and the consequent unnecessary antibiotic use and its associated problems, the role of quantitative cultures of respiratory secretions is pivotal Aims and objectives: To diagnose ventilator associated pneumonia by using quantitative endotracheal aspiration cultures and to identify the bacterial pathogens and determine the antimicrobial susceptibility pattern of those pathogens. Materials and methods: A prospective study was done which included 183 suspected cases of Ventilator associated pneumonia in SVS Medical College and Hospital for a period of one year and nine months. Quantitative endotracheal aspirate culture was done for all the samples, etiological agents were identified and antibiotic susceptibility was determined. Results: Out of 183 samples 102 samples () have shown significant number of colonies by quantitative cultures. Gram negative organisms isolated predominantly () followed by gram positive organisms (). Most common organism isolated was Acinetobacter baumanii () followed by Klebsiella pneumoniae (). In early onset VAP Klebsiella pneumonia was the most common while in late onset Acinetobacter baumanii was the most common. Multidrug resistance was common in all the isolates with Acinetobacter baumanii topping the list. Carbapenem resistance was observed in of Acinetobacter baumanii whereas in K. pneumoniae it is only 12%. Polymyxin B and colistin are the most susceptible drugs for Acinetobacter and Pseudomonas whereas in enterobacteriace (E. coli and K. pneumoniae) tigecycline was the best drug (0% resistance) followed by Imipenem (12% and resistance respectively). | Etiology, antibiogram and quantitative endotracheal aspirate cultures in ventilator associated pneumonia patients in a Tertiary care hospital

• Y khoa - Dược
• Ventilator associated pneumonia
• Nosocomial infection
• Tertiary care hospital
• Ventilator associated pneumonia patients
• Quantitative endotracheal aspirate cultures
• Intensive care unit
• Mechanical ventilation
• Ventilator associated event
• Bacteriological profile
• Mortality prognostic factors
• Diagnostic criteria
• Hospital acquired pneumonia
• Underlying diseases
• Ventilator associated tracheobronchitis
• Multi drug resistance
• Microbiological profile
• Bacterial profile
• Antimicrobial susceptibility pattern
• Multidrug resistant
• Geriatric VAP
• Extended Spectrum β lactamases
• ESBLs and MBLs
• Tissue culture plate method
• Multidrug resistance
• Biofilm production by organisms
• Biofilm production
• Pulmonary infection score
• Increases patient mortality
• Matrix metalloproteinases 9
• Lung inflammation
• Endotracheal aspirate
• Late onset ventilator associated pneumonia
• Bacteriological profile of early
• Former being predominant
• BMC Pediatrics
• Acinetobacter baumannii
• Carbapenem resistant
• Fractional inhibitor concentration
• Microbial profile
• Susceptibility pattern
• Microbial profile of pathogens causing
• Risk factors
• SRM medical college hospital
• A study under HICC
• BMC Pulmonary Medicine
• Early onset VAP
• Late onset VAP
• Adults receiving care
• Intensive care units
• Broad spectrum intravenous antibiotics
• Breath analysis
• Volatile organic compounds
• Empiric antibiotic treatment
• Cross infection
• Artificial respiration
• Critical care
• Clinical Pulmonary Infection Score
• Intensive care
• VAP diagnostics
• BMC Anesthesiology
• Heat and moisture exchangers
• Critically ill patients
• Contaminated material
• β Lactamase
• Gram negative bacteria
• Extended spectrum β Lactamase
• Amp C β Lactamase resistance
• Gram negative bacterial isolates
• Staphylococcus aureus
• Gram stain
• Tracheal aspirate
• Postoperative complications
• Ventilator induced lung injury
• Ventilator liberation
• BMC Genomics
• Controlled mechanical ventilation
• Ventilator induced diaphragm dysfunction
• Severe complications
• Nosocomial pneumonia
• Endotracheal tube cuff
• Endotracheal tube
• Pulmonary aspiration