TAILIEUCHUNG - Cytogenetic features in primary myelodysplastic syndrome Egyptian patients

Karyotype is the most important diagnostic and prognostic parameter in myelodysplastic syndromes (MDS) and is abnormal in approximately 50% of patients. We emphasized the importance of chromosomal analysis and reported the most frequent cytogenetic abnormalities in 50 MDS (29 males (58%) and 21 females (42%), median age: years) Egyptian patients using conventional banding analysis (CBA). Karyotype description was conducted according to the International System for Human Cytogenetic Nomenclature (ISCN, 2013). Patients were diagnosed based on complete history, bone marrow (BM) aspirate, peripheral blood (PBL) examination, and Iron stain. MDS with multilineage dysplasia (MDS-MLD) was the most frequently encountered subtype; 19/50 (38%) followed by MDS with single lineage dysplasia (MDS-SLD); 11/50 (22%). 27/50 patients (54%) showed a normal karyotype while 23 patients (46%) showed clonal nonrandom chromosomal abnormalities. Most patients with MDS with excess blasts-II (MDS-EB-II) showed abnormal karyotype (3/4; 75%) followed by MDS-EB-I (3/5, 60%) and MDS-MLD (10/19, 53%). Among 50 primary MDS patients; 14/50 (28%) had a single chromosomal abnormality, 3/50 (6%) had double chromosomal abnormality, and 6/50 (12%) had complex karyotype. Male sex was more frequently associated with higher IPSS prognostic risk categories than female gender. The most common single chromosomal abnormalities were 5/del5q; 7/50 (14%) patients followed by 7; 4/50 (8%) patients. +8, del20q and delY were each detected in 1/50 patient (2%). Abnormalities of chromosome 5 ( 5/del5q) as a single chromosomal abnormality was the most frequent chromosomal abnormality among Egyptian primary MDS patients followed by complex karyotype. Cytogenetic characteristics of MDS Egyptian patients were similar to North African and European patients. | Cytogenetic features in primary myelodysplastic syndrome Egyptian patients

• Y khoa - Dược
• Chromosomal abnormalities
• Cytogenetic features
• Primary myelodysplastic
• Syndrome Egyptian patients
• Most important diagnostic
• Lecture Principles of Biology
• Bài giảng Nguyên lý Sinh học
• Principles of Biology
• Chromosomal number
• Chromosomal structure
• Banding pattern
• Chromosomal heteromorphisms
• Karyotype abnormalities in humans
• Karyotype abnormalities
• Role of heteromorphic variations
• Wheat Triticum durum
• Mitotic abnormalities
• Chromosomal behavior
• Wheat seeds
• Genomic hybridization
• Neuroblastoma patient
• Remarkable biological heterogeneity
• Numerical chromosomal abnormalities
• Segmental chromosomal abnormalities
• Zea mays
• Chromosomal anomalies
• Cytological abnormalities
• Meiotic abnormalities
• Mercury chloride
• Cadmium chloride
• Chromosome abnormalities
• Genetic counseling
• Chromosome analysis
• Autosomal ring chromosomes
• Robertsonian translocations
• Normal chromosomal variation
• Gametic cells of soybean
• Meiotic irregularities
• Inducing chromosomal
• Pollen fertility
• Dichlorophenoxy acetic acid
• Tritium aestivum L
• Relative division rate
• Relative abnormality rate
• Pediatric pathology
• Placental pathology
• Hydrops fetalis
• Perinatal chromosomal abnormalities
• Malformation syndromes
• Congenital anomalies
• Key topics in neonatology
• Childbirth complications
• Congenital diaphragmatic hernia
• Extreme prematurity
• BMC Pediatrics
• Copy number alterations
• Myelodysplastic syndrome
• Genetic change
• Journal of Biology
• Tagetes patula
• Allium test
• Fusarium moniliforme
• Pythium ultimum
• Double test
• Triple test
• Non invasive prenatal testing
• Fetal aneuploidy
• BMC Cancer
• Malignant teratoma
• Germ cells
• Extra gonadal malignant teratomas
• Cluding chromosomal abnormalities
• E coli
• Colorectal cancer
• Galacto oligosaccharides
• DNA double strand breaks