TAILIEUCHUNG - QbD based approach for optimization of Tenofovir disoproxil fumarate loaded liquid crystal precursor with improved permeability

BCS class III drugs suffer from a drawback of low permeability even though they have high aqueous solubility. The objective of current work was to screen the suitability of glyceryl monooleate (GMO)/Pluronic F127 cubic phase liquid crystals precursors for permeation enhancement and in turn the bioavailability of tenofovir disoproxil fumarate (TDF), a BCS class III drug. Spray-drying method was used for preparation of TDF loaded liquid crystal precursors (LCP) consisting of GMO/Pluronic F127 and lactose monohydrate with an ability to in situ transform into stable cubic phases upon hydration. The quality by design (QbD) approach (Factorial design) was used for batch optimization. Spherical TDF loaded LCP as revealed by scanning electron microscopy photographs when hydrated and analyzed by small angle X-ray scattering confirmed formation of cubic phase. Differential scanning calorimetry and X-ray diffraction studies confirmed the molecular dispersion of TDF in polymer matrix and also suggested the conversion of TDF from crystalline to amorphous form. In vitro TDF release from prepared LCP showed controlled drug release over a period of 10 h. Further ex vivo studies revealed permeation enhancing activity of prepared LCP, which was highest when tested in presence of digestive enzyme extract. Thus, formulation of stable liquid crystal powder precursor can serve as an alternative for designing oral delivery system for drugs with low permeability. | QbD based approach for optimization of Tenofovir disoproxil fumarate loaded liquid crystal precursor with improved permeability

• Sinh học
• Liquid crystal precursor
• Glyceryl monooleate
• Tenofovir disoproxil fumarate
• Quality by design
• Permeation flux
• Factorial design
• Experimental Design
• Fractional Factorial Experiments
• Factorial Experiments
• Single Factor
• Data Sets
• Regression Analysis
• Adjusted median transform
• Adjusted rank transform test
• Nonparametric statistical test
• Classical factorial F test
• AMT and ART test
• BMC Musculoskeletal Disorders
• Chronic back pain
• Transcranial direct current stimulation
• Transcutaneous electrical nerve stimulation
• Randomized clinical trial
• Chemical activation
• Palm kernel shell
• Activated carbon
• Full factorial design
• Palm kernel shells
• báo cáo khoa học
• báo cáo hóa học
• công trình nghiên cứu về hóa học
• tài liệu về hóa học
• cách trình bày báo cáo
• báo cáo y học
• công trình nghiên cứu về y học
• tài liệu về y học
• Data structures and Algorithms
• Outline of a Recursive Function
• Recursive Factorial Method
• Fibonacci sequence
• Design a Recursive Algorithm
• Multiple recursion
• Recursion Data structures
• Tracing fib
• Controlled porosity osmotic pump tablets
• Response surface methodology
• Directly compressed cores
• Timolol maleate
• Transdermal transfersomal gel
• Statistical optimization
• Pharmacokinetic assessment
• BMC Pediatrics
• Chronic suppurative otitis media
• Povidone iodine
• Randomised controlled trial
• Significant health
• Integrated nutrient management
• Different plant spacing on Tulsi
• Factorial randomized block design
• Treatments consisted
• Yield attributing character
• Black gram
• Inorganic fertilizers
• Each replicated three times
• Said growth parameters
• Journal of Chemistry
• Thin film
• Optical property
• Vanadium(V) oxide xerogel
• BMC Anesthesiology
• Physiologic response
• Intense inflammatory response
• Perioperative inflammation promotes
• Increases mortality
• Surgical trauma
• Early nutrition
• Neurodevelopmental outcome
• Taste and smell
• Randomised factorial design
• Yield attributes
• Effect of nitrogen
• Phosphorus on yield
• Yield attributes of maize
• Growth and yield
• Spacing and training on growth
• Yield of polyhouse grown cucumber
• Polyhouse grown cucumber
• Following factorial completely randomized design