TAILIEUCHUNG - Expression of miR - 122 plasma as a biomarker for hepatocellular carcinoma

In this study, we aim to evaluate the expression of microRNAs-122 plasma, and combination of microRNAs-122 with alpha-fetoprotein to diagnosis of hepatocellular carcinoma. | Journal of military pharmaco-medicine n09-2018 EXPRESSION OF miR-122 PLASMA AS A BIOMARKER FOR HEPATOCELLULAR CARCINOMA Dang Chieu Dương1; Phan Quoc Hoan2; Le Huu Song2 Nguyen Linh Toan3; Ngo Tat Trung2 SUMMARY Objectives: MicroRNAs participate in cell proliferation, apoptosis and transformation. However, the use of microRNAs-122 in combination with alpha-fetoprotein has not been evaluated. In this study, we aim to evaluate the expression of microRNAs-122 plasma, and combination of microRNAs-122 with alpha-fetoprotein to diagnosis of hepatocellular carcinoma. Subjects and methods: Real-time PCR was employed to measure microRNAs-122 expression levels on 250 plasma samples of 101 patients with hepatitis B virus-related hepatocellular carcinoma, 46 chronic hepatitis B patients and 103 healthy controls. Results: The relative expression levels of microRNAs-122 in hepatitis B virus-related hepatocellular carcinoma patients were higher than chronic hepatitis B and healthy controls (p < ). The individual microRNAs-122 acquired high diagnostic accuracy for hepatocellular carcinoma surveillance (hepatocellular carcinoma vs. chronic hepatitis B, AUC = ; hepatocellular carcinoma vs. healthy controls, AUC = ). When alpha-fetoprotein levels were lower than 20 ng/mL, microRNAs-122 still preserves accuracy to distinguish hepatocellular carcinoma from other groups (chronic hepatitis B, AUC = ; healthy controls, AUC = ). When microRNAs122 were used in combination with alpha-fetoprotein levels, the diagnostic performance was significantly improved in discriminating hepatocellular carcinoma from group chronic hepatitis B (AUC = ). Conclusions: MicroRNAs-122 is a potential biomarker to improve diagnostic in hepatitis B virus-related hepatocellular carcinoma patients, especially in patients with hepatocellular carcinoma with normal alpha-fetoprotein level. * Keywords: Hepatocellular carcinoma; MicroRNAs-122; Alpha-fetoprotein. INTRODUCTION Liver cancer is

• Y khoa - Dược
• Hepatocellular carcinoma
• MicroRNAs 122
• Alpha fetoprotein
• Computed tomography
• Magnetic resonance imaging
• Gamma carboxy prothrombin
• Summary of doctoral thesis in medicine
• Clinical of hepatocellular carcinoma and paraclinical
• Histopathology of hepatocellular carcinoma
• Immunohistochemical characteristics of hepatocellular carcinoma
• Portal vein thrombosis
• Involving factors in pateins with PVT
• BMC Cancer
• Hepatocellular proliferation
• P53 ubiquitination
• Hepatocellular cells
• Anti tumor role
• TNF α 308 polymorphism
• Hepatocellular carcinoma risk
• 102 healthy blood donors
• Chronic hepatitis B virus
• Molecular markers
• Prognostic system
• Associated HCV infection
• Circulating miRNAs
• Viral etiology
• Stereotactic body radiation therapy
• Small hepatocellular carcinoma
• Radiofrequency ablation
• Small ubiquitin related modifier
• HBV associated hepatocellular carcinoma
• HEK 293T cells
• Systemic therapy
• Systemic therapy for hepatocellular carcinoma
• Adjuvant regimens for HCC
• Sorafenib was first approved
• Prolong survival of the patients
• Barcelona Classification
• Non alcoholic fatty liver disease
• Visceral fat
• Metabolic syndrome
• Journal of Chemistry
• 7 Ethyl 10 hydroxycamptothecin
• Anticancer drug irinotecan
• Anticancer agent against HCC
• Hepatocellular carcinoma (HCC)
• Clinical of patients
• Laboratory characteristics
• Prognosis of patients with hepatocellular carcinoma
• Clinical presentation
• Prognostic model
• Hepatitis C virus
• Direct acting antiviral agents
• Treating chronic hepatitis C infection
• Real time PCR HRM
• Molecular genotyping assay
• Reaction high resolution melting
• Transcatheter arterial chemoembolization
• Clinical trial
• Advanced hepatocellular carcinoma
• Delayed reaction
• High fever
• Ectopic hepatocellular carcinoma
• Western blot
• Carcinoma remains unclear
• Quantitative reverse transcription PCR
• Combined hepatocellular
• Progenitor cell
• Hippo pathway
• Metallothionein 1H
• Wnt/β catenin
• Hepatocellular cancer
• Including hepatocellular cancer
• Scientific reports
• scientific research
• Structural biochemistry
• phosphatase
• medical analysis
• Epidemiology
• Risk Factors
• Surgical Treatment
• Liver Metastases
• Tạp chí khoa học
• The short term outcome of radiofrequency ablation
• Hepatocellular carcinoma at Binh Dan hospital
• Binh Dan hospital
• Short term outcome of radiofrequency ablation
• Complete ablation rate
• Tumor progression
• Intra nodular
• Peripheral enhancement
• Diagnostic accuracy of PIVKA II
• Combination of both in diagnosis
• Vitamin K absence