TAILIEUCHUNG - Analysis of the association between the Gly972Arg polymorphism in IRS1 gene and the risk of prediabetes among vietnamese women

The frequency of the ‘‘A’’ allele of the Gly972Arg (G>A) polymorphism was similar between the normal glucose and prediabetic subjects ( and , respectively). There was no significant difference in the genotypic frequency between the control and prediabetic cases (P = ). The IRS1 Gly972Arg polymorphism was not associated with the risk of prediabetes in Vietnamese women both before and after being adjusted for socio-economic, lifestyle and clinical factors (P > ). | VNU Journal of Science: Medical and Pharmaceutical Sciences, Vol. 34, No. 2 (2018) 82-88 The Association between the Gly972Arg Polymorphism in IRS1 Gene and the Risk of Prediabetes among Vietnamese Women Nguyen Thi Trung Thu1, Tran Quang Binh2,* 1 Falcuty of Biology, Hanoi National University of Education, 136 Xuan Thuy, Cau Giay, Hanoi, Vietnam 2 Department of Scientific Management, National Institute of Nutrition, 48B Tang Bat Ho, Pham Đinh Ho, Hai Ba Trung, Hanoi, Vietnam Received 26 October 2018 Revised 07 November 2018; Accepted 25 December 2018 Abstract: Insulin receptor substrate 1 (IRS1), a ligand of the insulin receptor tyrosine kinase, participates in the insulin receptor signal transduction pathway. Dysregulations in IRS1 expression and function increase incidence of insulin-resistant states such as prediabetes and type 2 diabetes. The study was aimed at investigating the association of the Gly972Arg (rs1801278) polymorphism in IRS1 gene with prediabetes in Northern Vietnamese women. The case-control study consisted of 1,617 women (250 prediabetic cases and 1,367 normoglycemic controls). The IRS1 Gly972Arg polymorphism was genotyped in these subjects using polymerase chain reaction–restriction fragment length polymorphism. The frequency of the ‘‘A’’ allele of the Gly972Arg (G>A) polymorphism was similar between the normal glucose and prediabetic subjects ( and , respectively). There was no significant difference in the genotypic frequency between the control and prediabetic cases (P = ). The IRS1 Gly972Arg polymorphism was not associated with the risk of prediabetes in Vietnamese women both before and after being adjusted for socio-economic, lifestyle and clinical factors (P > ). Keywords: Gly972Arg, polymorphism, IRS1 gene, prediabetes, Vietnamese women. 1. Introduction diabetes and varies among populations and ethnic groups. According to the report of Centers for Disease Control and Prevention prevalence of diabetes and .

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