TAILIEUCHUNG - Synthesis and structural characteristics of platinum(II) complexes with N(4)-substituted thiosemicarbazones
The analysis of IR, UV-vis, MS, 1H-NMR, 13C-NMR, COSY, and HSQC illustrated that HL1, HL2, HL3 were bidentate ligands and bound to the metal through the imine nitrogen and the net negatively charged sulfur in thiol form. Furthermore, it was demonstrated that the chelating ligands in the Pt(II) complexes were in the trans configuration. | Vietnam Journal of Chemistry, International Edition, 54(4): 459-466, 2016 DOI: Synthesis and structural characteristics of platinum(II) complexes with N(4)-substituted thiosemicarbazones Duong Ba Vu1*, Tran Buu Dang1,2 1 Faculty of Chemistry, Ho Chi Minh City University of Education, Vietnam 2 Faculty of Chemistry, Ho Chi Minh City University of Science, Vietnam Received 7 March 2016; Accepted for publication 12 August 2016 Abstract Three ligands, namely 4-nitrobenzaldehyde-[N(4)-methyl, N(4)-phenyl thiosemicarbazone] (HL1), fluoren-9one-[N(4)-(4-methylpiperidinyl)thiosemicarbazone] (HL2), and 4’-hydroxyacetophenone-[N(4)-(4methylpiperidinyl)thiosemicarbazone] (HL3) as well as three corresponding Pt(II) complexes ([Pt(Li)2](i = 1;2;3)), were synthesized and fully characterized. The analysis of IR, UV-vis, MS, 1H-NMR, 13C-NMR, COSY, and HSQC illustrated that HL1, HL2, HL3 were bidentate ligands and bound to the metal through the imine nitrogen and the net negatively charged sulfur in thiol form. Furthermore, it was demonstrated that the chelating ligands in the Pt(II) complexes were in the trans configuration. Keywords. Thiosemicarbazone, platinum(II) complexes, coordination compounds, inorganic synthesis. 1. INTRODUCTION Thiosemicarbazone (TSC) ligands are a large group of thiourea derivatives which have attracted much interest due to their antiviral, antimalarial, antifungal, antimicrobial, and antitumor activities [111]. In solution state, they can undergo tautomerization to thiol form as depicted in Scheme 1 [4-11]. Scheme 1: The tautomerization of TSC in solution The conjugated N-N-S tridentate ligand system of TSCs plays an essential role for anticancer activity, as they are reliable to function as prospective inhibitors of ribonucleotide reductase activity [2, 12, 13]. For the reason that TSCs can chelate with trace metals in biological systems, transition metal complexes with N(4)thiosemicarbazone ligands have also .
đang nạp các trang xem trước
