TAILIEUCHUNG - A cytotoxic stilbenoid and two benzoic acids from stemona peirrei plants growing in laos

Three non-alkaloidal metabolites, stemanthrene C, p-anisic and benzoic acids, were isolated from the roots of Stemona peirrei plants, collected in Savannakhet province (Laos). Their structures were elucidated by spectroscopic analyses. Stemanthrene C exhibited medium cytotoxic activity against KB cell line with IC50 value of µg mL-1 | Nguyễn Thị Nhàn và Đtg Tạp chí KHOA HỌC & CÔNG NGHỆ 102(02): 151 - 154 Ngày nhận bài:30/1/2013, ngày phản biện: 18/2/2013, ngày duyệt đăng:26/3/2013 A CYTOTOXIC STILBENOID AND TWO BENZOIC ACIDS FROM STEMONA PEIRREI PLANTS GROWING IN LAOS Nguyen Thi Nhan1, Vong Anatha Khamko1,2, Nguyen Thu Ha1,3, Dang Ngoc Quang1, Pham Huu Dien1* 1 Hanoi National University of Education, 136 Xuan Thuy Str., Hanoi, Vietnam 2 Savannakhet University, K. Phomvihane Distr., Savannakhet Province, Laos 3 Hanoi College of Pharmacy, Minhkhai Comm., Tuliem Distr., Hanoi, Vietnam SUMMARY Three non-alkaloidal metabolites, stemanthrene C, p-anisic and benzoic acids, were isolated from the roots of Stemona peirrei plants, collected in Savannakhet province (Laos). Their structures were elucidated by spectroscopic analyses. Stemanthrene C exhibited medium cytotoxic activity against KB cell line with IC50 value of µg mL-1. Keywords: Stemona peirrei, stemanthrene C, p-anisic acid, benzoic acid, cytotoxic activity INTRODUCTION* Various species of the genus Stemona (Stemonaceae) are widely used in Vietnam, Laos and other countries of southeast Asia as an anticough remedy and for their antiparasitic properties. Especially, extracts from the tuberous roots of Lour., S. saxorum Gagnep., S. cochinchinensis . have been recommended in Vietnamese, Laos’ traditional medicine for a broad range of applications, such as to relieve cough and asthma, to be used for against enteric helminths and ectoparasites on human and cattle [1-4]. Chemical investigations on Stemona genus have resulted in the isolation of more than 90 different alkaloids, most of which share the common pyrrolo[1,2a]azepine basic nucleus, a minor fraction also containing the pyrido[1,2-a]azepine skeleton [5-7]. However, the non-alkaloids * Tel: 0912 109836, Email: dienph@ components of this genus have been rarely investigated yet: less than 20 compounds, mostly belonging to dihydrophenanthrenes and .

• Hoá học
• Three non alkaloidal metabolites
• A Cancer cell
• A cytotoxic stilbenoid
• Two benzoic acids
• Stemona peirrei plants