TAILIEUCHUNG - The comparison of antioxidant capacity and cytotoxic, anticarcinogenic, and genotoxic effects of FeAu nanosphere magnetic nanoparticles
Magnetic gold nanoparticles are used in various biomedical, biochemistry, and biotechnology applications due to their controllable size distribution, long-term stability, reduced toxicity, and biocompatibility. | Turkish Journal of Biology Turk J Biol (2017) 41: 302-313 © TÜBİTAK doi: Research Article The comparison of antioxidant capacity and cytotoxic, anticarcinogenic, and genotoxic effects of Fe@Au nanosphere magnetic nanoparticles 1 1 2 3 Hande YEĞENOĞLU , Belma ASLIM , Burcu GÜVEN , Adem ZENGİN , 2 1 4, İsmail Hakkı BOYACI , Zekiye SULUDERE , Uğur TAMER * 1 Department of Biology, Faculty of Science, Gazi University, Ankara, Turkey 2 Department of Food Engineering, Faculty of Engineering, Hacettepe University, Ankara, Turkey 3 Department of Chemical Engineering, Faculty of Engineering, Yüzüncü Yıl University, Van, Turkey 4 Department of Analytical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey Received: Accepted/Published Online: Final Version: Abstract: Magnetic gold nanoparticles are used in various biomedical, biochemistry, and biotechnology applications due to their controllable size distribution, long-term stability, reduced toxicity, and biocompatibility. Different coating materials, such as proteins, carbohydrates, lipids, and polyphenols, are applied to enhance the biocompatibility of nanoparticles. In this study, the effects of surface coatings of core-shell structured Fe@Au nanosphere magnetic nanoparticles with regard to antioxidant capacity and cytotoxic, anticarcinogenic, and genotoxic properties were investigated. The obtained results demonstrated that avidin-coated Fe@Au nanospheres had higher antioxidant capacities than uncoated nanospheres. Neither avidin-coated nor uncoated nanoparticles had a cytotoxic effect on normal cells (human gingival fibroblast cell line, HGF-1). In addition, they had anticarcinogenic effects on human cervical carcinoma (HeLa), human breast adenocarcinoma (MCF-7), and human colorectal adenocarcinoma (CCL-221). The genotoxic effects of nanoparticles were also evaluated with DNA tail damage ratio. Key words: .
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