TAILIEUCHUNG - Comparison of GST isoenzyme expression in normal and neoplastic breast tissue: correlation with clinical and prognostic factors

Glutathione S-transferases in breast tissue play an important role in the susceptibility to the mutagenic effects of chemical carcinogens and in the response of breast tumors to chemotherapy. | Turk J Biol 33 (2009) 89-100 © TÜBİTAK doi: Comparison of GST Isoenzyme Expression in Normal and Neoplastic Breast Tissue: Correlation with Clinical and Prognostic Factors Serpil OĞUZTÜZÜN1, Mesude İŞCAN2, Müzeyyen ÖZHAVZALI3, Serpil DİZBAY SAK4 1 2 Department of Biology, Faculty of Arts and Sciences, Kırıkkale University, 71450 Yahşihan-Kırıkkale - TURKEY Department of Biological Sciences, Faculty of Arts and Sciences, Middle East Technical University 06531 Ankara - TURKEY 3 Department of Mathematics, Faculty of Arts and Sciences, Kırıkkale University, 71450 Yahşihan-Kırıkkale - TURKEY 4 Department of Pathology, Faculty of Medicine, Ankara University, Ankara - TURKEY Received: Abstract: Glutathione S-transferases in breast tissue play an important role in the susceptibility to the mutagenic effects of chemical carcinogens and in the response of breast tumors to chemotherapy. In this study the immunohistochemical staining characteristics of glutathione S-transferase isoenzymes (alpha, mu, pi, and theta) were investigated in invasive duct carcinomas and in normal breast tissue of 43 patients. The relationships between the expression of the GST isoenzymes and some clinicopathological features were also examined. Diffuse cytoplasmic staining of varying intensity was observed for GST alpha, theta, and pi in normal and tumorous breast tissue in 100% of the samples. In normal epithelium there was a stronger intensity of staining for GST alpha, mu, and pi expression than in invasive tumor tissues (P ). In this study significant relationships were observed between microcalcification status and GST mu, between menopause status and GST alpha, and between tumor grade and GST mu expression (P ). Key Words: Glutathione-S-transferase, breast cancer, immunohistochemistry Normal ve Tümörleşmiş Meme Dokusunda GST İzozimlerinin Ekspresyonlarının Karşılaştırılması: Klinik ve Prognoz Faktörlerle İlişkisi Özet: Meme dokusunda bulunan .

• Sinh học
• Glutathione S transferase
• Breast cancer
• GST isoenzymes
• Tumor epithelial cells
• Hormone therapy status
• BMC Cancer
• Triple negative
• Estrogen receptor
• Progesterone receptor