TAILIEUCHUNG - Some triterpenoids and steroids from the lichen lobaria orientalis, lobariaceae
Chemical investigation of the ethyl acetate extract of the lichen Lobaria orientalis, Lobariaceae, collected in Vietnam, afforded six known compounds, including four triterpenoids, zeorin (1), 16β-acetoxyhopane-6α,22-diol (2), retigeric acid A (3), retigeric acid B (4), together with two steroids, ergosterol-5α,8α-peroxide (5) and cerevisterol (6). | Journal of Science and Technology 54 (2C) (2016) 313-319 SOME TRITERPENOIDS AND STEROIDS FROM THE LICHEN LOBARIA ORIENTALIS, LOBARIACEAE. Nguyen Thi My Dung1, Pham Nguyen Kim Tuyen2, Jacques Mortier3 , Nguyen Kim Phi Phung1, * 1 Department of Organic Chemistry, University of Science, National University HCM City, 227 Nguyen Van Cu Str., Dist. 5, Ho Chi Minh City 748355, Vietnam 2 3 Sai Gon University, Ho Chi Minh City, 748355, Vietnam Institute for Molecules and Material, University of Maine, Avenue Olivier Messiaen 72085 Le Mans Cedex, France * Email: kimphiphung@ Received: 30 May 2016; Accepted for publication: 23 October 2016 ABSTRACT Chemical investigation of the ethyl acetate extract of the lichen Lobaria orientalis, Lobariaceae, collected in Vietnam, afforded six known compounds, including four triterpenoids, zeorin (1), 16β-acetoxyhopane-6α,22-diol (2), retigeric acid A (3), retigeric acid B (4), together with two steroids, ergosterol-5α,8α-peroxide (5) and cerevisterol (6). Their chemical structures were elucidated by spectroscopic data analysis and comparison with those reported in the literature. The cytotoxic activities of some compounds against liver hepatocellular carcinoma (HepG2), human lung cancer (NCI-H460), human epithelial carcinoma (HeLa) and human breast cancer (MCF-7) cell lines were evaluated. Compound 2 exhibited good cytotoxicity against MCF-7 cancer cell line with IC50 value of µg/mL. This is the first time compounds (1), (2), (6) are reported in the Lobaria genus. Keywords: Lobaria orientalis, lichen, triterpenoid, steroid, HepG2, NCI-H460, HeLa, MCF-7. 1. INTRODUCTION Lichens, symbiotic products of mycobiont (fungal partner) and photobiont (algal partner), are known to produce a various range of secondary metabolites which possessed a wide range of biological activities including antibiotic, antifungal, antiviral, antitumor, anticancer, etc.[1 - 4] The Lobaria genus was known to contain compounds such as depsidones .
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