TAILIEUCHUNG - Lecture Molecular biology (Fifth Edition): Chapter 20 - Robert F. Weaver

Chapter 20 - DNA replication, damage, and repair. In chapter 3 we learned that genes have three main activities. One is to carry information, and we have spent most of the intervening chapters examining how cells decode this information through transcription and translation. Another activity of genes is to participate in replication. The next two chapters will examine this process in detail. In this chapter we will also consider DNA damage and repair. | Molecular Biology Fifth Edition Chapter 20 DNA Replication, Damage, and Repair Lecture PowerPoint to accompany Robert F. Weaver Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. General Features of DNA Replication Double helical model for DNA includes the concept that 2 strands are complementary Each strand can serve as template for making its own partner Semiconservative model for DNA replication is correct Half-discontinuous (short pieces later stitched together) Requires DNA primers Usually bidirectional 20- Three Hypotheses of Replication The three methods of DNA replication considered were: Semiconservative Conservative Dispersive 20- DNA replicates in a semiconservative manner When parental strands separate Each strand serves as template Makes a new, complementary strand Semiconservative Replication 20- Semidiscontinuous Replication DNA replication in E. coli (and in other organisms) is semidiscontinuous One strand (the

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