TAILIEUCHUNG - Lecture Genetics: From genes to genomes - Chapter 10: Genomes and proteomes
Chapter 10 introduce to the genomes and proteomes. The main contents of this chapter include all of the following: Large-scale genome mapping and analysis, major insights from the human and model organism genome sequences, global analysis of genes and their mRNAs, global analysis of proteomes, repercussions of the human genome project and high-throughput technology. | PowerPoint to accompany Genetics: From Genes to Genomes Fourth Edition Leland H. Hartwell, Leroy Hood, Michael L. Goldberg, Ann E. Reynolds, and Lee M. Silver Prepared by Mary A. Bedell University of Georgia Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display CHAPTER What Genes Are and What They Do CHAPTER PART III CHAPTER OUTLINE Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition, Chapter 10 Genomes and Proteomes Large-Scale Genome Mapping and Analysis Major Insights from the Human and Model Organism Genome Sequences Global Analysis of Genes and Their mRNAs Global Analysis of Proteomes Repercussions of the Human Genome Project and High-Throughput Technology Genomics is the study of whole genomes Genomics involves the development and application of more effective mapping, sequencing, and computational tools Predict existence and functions of previously undefined genes Verify predictions using molecular biology techniques Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition, Chapter 10 The Human Genome Project (HGP) First formally discussed in 1985 Discovery science – identification of all elements in a biological system Contrast to hypothesis-driven research Development of high throughput sequencing technology and computational tools Officially began in 1990 – estimated 15 years, $3 billion 3-5% of budget committed to studying the ethical, legal, and social implications (ELSI) of human genome mapping Social and personal repercussions are generating new areas of biological concern Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition, Chapter 10 DNA sequence coverage of the first rough draft of the human genome 2001 - draft sequence (93% of genome) Error rate of 1/10,000 2003 - accurate .
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