TAILIEUCHUNG - Lecture Molecular biology: Chapter 2 - Robert F. Weaver

Chapter 2 - The molecular nature of genes. Before we begin to study in detail the structure and activities of genes, and the experimental evidence underlying those concepts, we need a fuller outline of the adventure that lies before us. Thus, in this chapter and in chapter 3, we will fl esh out the brief history of molecular biology presented in chapter 1. In this chapter we will begin this task by considering the behavior of genes as molecules. | Molecular Biology Fourth Edition Chapter 2 The Molecular Nature of Genes Lecture PowerPoint to accompany Robert F. Weaver Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. The Nature of Genetic Material Historical Background Miescher isolated nuclei from pus (white blood cells) in 1869 Found a novel phosphorus-bearing substance = nuclein Nuclein is mostly chromatin, a complex of DNA and chromosomal proteins End of 19th century – DNA and RNA separated from proteins Levene, Jacobs, et al. characterized basic composition of DNA and RNA 2- Transformation in Bacteria Key experiments done by Frederick Griffith in 1928 Observed change in Streptococcus pneumoniae — from virulent (S) smooth colonies where bacterial had capsules, to avirulent (R) rough colonies without capsules Heat-killed virulent colonies could transform avirulent colonies to virulent ones 2- Outline of Griffith’s Transformation Experiments 2- DNA: The Transforming .

• Sinh học
• Molecular biology
• Lecture Molecular biology
• Sinh học phân tử
• Genetic material
• Transforming material
• DNA structure
• High Yield cell and molecular biology
• Cell and molecular biology
• The cell cycle
• Molecular biology of cancer
• Cell biology of the immune system
• Molecular biology techniques
• Identification of human disease genes
• Campbell biology
• Lecture Campbell biology
• Biological sciences
• Systems biology
• Molecular biology of the gene
• Chromosome replication
• Meiosis and genetic recombination
• The human nuclear genome
• The human mitochondrial genome
• Molecular cloning methods
• Gene cloning
• Directional cloning
• Amino acids
• Molecular tools
• Studying genes
• History of genetics
• Both simple
• Molecular genetics
• Genetic code
• Molecular biology of microorganisms
• Different facets
• Plant molecular biology
• Genetic manipulation
• Recombinant DNA technology
• Molecular diagnostics
• Biochemistry cell and molecular biology test
• Molecular Biology Test
• Biochemistry Test
• Genetics test
• Structural Biology
• Cupramolecular complexes
• Lecture Biology
• Mendel’s Laws
• Transmission genetics
• Mendel’s gene transmission
• Gene function
• Storing information
• Mechanism of transcription
• RNA polymerase structure
• Lac operon
• Bacterial transcription
• Sigma factor switching
• DNA Protein interactions
• The λ family of repressors
• Eukaryotic RNA polymerases
• RNA polymerases
• Class II factors
• Transcription activators in eukaryotes
• RNA polymerase II
• Histones in the nucleosome
• Nucleosome structure
• Messenger RNA processing I
• Genes in pieces
• RNA processing II
• Cap structure
• Cytoplasmic polyadenylation
• RNA processing
• Ribosomal RNA processing
• Transfer RNA processing