TAILIEUCHUNG - OSTEOARTHRITIS - National clinical guideline for care and management in adults

None of the newer evidence altered the priority given to metformin cited in the previous guideline. Although the specific cardioprotective effects of metformin suggested by the UKPDS study were open to challenge from some of the very recent studies, this was not on the basis of strong outcome data. Large observational studies from Canada and Scotland111,112 appeared to support the widespread advantage of metformin over sulfonylureas, but the A Diabetes Outcome Progression Trial (ADOPT) study did not. The cardioprotective gains shown in the UKPDS and in the Scottish study far outweighed the concerns over lactic acidosis (provided renal function was adequate) in people with mild to moderate. | The National Collaborating Centre for Chronic Conditions Funded to produce guidelines for the NHS by NICE OSTEOARTHRITIS National clinical guideline for care and management in adults Published by Royal College of Physicians Setting higher medical standards Osteoarthritis Mission statement The Royal College of Physicians plays a leading role in the delivery of high quality patient care by setting standards of medical practice and promoting clinical excellence. We provide physicians in the United Kingdom and overseas with education training and support throughout their careers. As an independent body representing over 20 000 Fellows and Members worldwide we advise and work with government the public patients and other professions to improve health and healthcare. The National Collaborating Centre for Chronic Conditions The National Collaborating Centre for Chronic Conditions NCC-CC is a collaborative multiprofessional centre undertaking commissions to develop clinical guidance for the NHS in England and Wales. The NCC-CC was established in 2001. It is an independent body housed within the Clinical Standards Department at the Royal College of Physicians of London. The NCC-CC is funded by the National Institute for Health and Clinical Excellence NICE to undertake commissions for national clinical guidelines on an annual rolling programme. Citation for this document National Collaborating Centre for Chronic Conditions. Osteoarthritis national clinical guideline for care and management in adults. London Royal College of Physicians 2008. ISBN 978-1-86016-329-6 ROYAL COLLEGE OF PHYSICIANS 11 St Andrews Place London NW1 4LE Registered charity No 210508 Copyright 2008 Royal College of Physicians of London All rights reserved. No part of this publication may be reproduced in any form including photocopying or storing it in any medium by electronic means and whether or not transiently or incidentally to some other use of this publication without the written

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