TAILIEUCHUNG - Ebook The paris system for reporting urinary cytology: Part 2

(BQ) Part 2 book "The paris system for reporting urinary cytology" presents the following contents: High-Grade urothelial carcinoma (HGUC), low grade urothelial neoplasia (LGUN), other malignancies primary and metastatic and miscellaneous lesions, ancillary studies in urinary cytology, cytopreparatory techniques, clinical management. | Chapter 6 High-Grade Urothelial Carcinoma HGUC Momin T. Siddiqui Guido Fadda Jee-Young Han Christopher L. Owens Z. Laura Tabatabai and Toyonori Tsuzuki Background Historical Review of Reporting System of Urine Cytology Urine cytology is an important test for screening and diagnosis of newly developed urothelial carcinoma UC and for surveillance of UC recurrence and new neoplasms. Urine cytology has been used for a long time because of its merits such as easy availability and noninvasive testing high sensitivity and specificity for high-grade urothelial carcinoma HGUC and great effectiveness to evaluate the entire urothelial tract. With urine cytology the high-grade malignant cells can be identified even in occult carcinoma that is not visible cysto-scopically 1 2 . Therefore despite the low sensitivity for low-grade urothelial neoplasm LGUN and the development of several newer techniques such as fluorescence in situ hybridization FISH for screening and diagnosis of UC urine cytology still remains the gold standard for bladder cancer screening especially for HGUC. The reporting system for urine cytology has evolved over a period of time according to the changes in the histopathologic classification of UC 3 . Initially Dr. Papanicolaou suggested a reporting system of urine cytology that included five classes 4 . Although this reporting system had a great role in diagnosing high-grade UC the definitions or criteria for each category were somewhat unclear 4 . On the basis of the histopathologic classification of bladder cancer by the 1973 World Health Organization WHO classification Koss et al. reported a new classification scheme for urine cytology 5 . In this classification HGUC was characterized by the presence of hyperchromasia and nuclear membrane abnormalities in the malignant cells. After changes in the histopathologic classification of UC by the WHO International Society of Urological Pathology in 1998 the Papanicolaou Society of Cytopathology PSC Task Force .

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• The paris system for reporting urinary cytology
• High Grade urothelial carcinoma
• Low grade urothelial neoplasia
• Other malignancies primary
• Miscellaneous lesions
• Cytopreparatory techniques
• Pathogenesis of urothelial carcinoma
• Adequacy of urine specimens
• Negative for high grade urothelial carcinoma
• Atypical urothelial cells