TAILIEUCHUNG - Báo cáo khoa học: Tec family kinases Itk and Rlk⁄ Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates

Developing thymocytes and T cells express the Tec kinases Itk, Rlk⁄Txk and Tec, which are critical modulators of T-cell receptor signaling, required for full activation of phospholipase Cc, and downstream Ca 2+ and ERK-mediated signaling pathways. | ịFEBS Journal MINIREVIEW Tec family kinases Itk and Rlk Txk in T lymphocytes cross-regulation of cytokine production and T-cell fates Julio Gomez-Rodriguez Zachary J. Kraus and Pamela L. Schwartzberg NationalHuman Genome Research Institute National institutes of Health Bethesda MD USA Keywords cytokines innate lymphocytes Itk PLZF Rlk Txk T-helper cells Th1 Th2 Th17 thymus Correspondence P. L. Schwartzberg NationalHuman Genome Research Institute National Institutes of Health Bethesda MD 20892 USA Fax 1 301 402-2170 Tel 1 301 435-1906 E-mail pams@ Received 1 September 2010 revised 2 December 2010 accepted 25 February 2011 doi Developing thymocytes and T cells express the Tec kinases Itk Rlk Txk and Tec which are critical modulators of T-cell receptor signaling required for full activation of phospholipase Cy and downstream Ca2 and ERK-mediated signaling pathways. Over the last 10 years data have implicated the Tec family kinases Itk and Rlk Txk as important regulators of cytokine production by CD4 effector T-cell populations. Emerging data now suggest that the Tec family kinases not only influence cytokine-producing T-cell populations in the periphery but also regulate the development of distinct innate-type cytokine-producing T-cell populations in the thymus. Together these results suggest that the Tec family kinases play critical roles in helping shape immune responses via their effects on the differentiation and function of distinct cytokine-producing effector T-cell populations. Introduction Among the key players in intracellular signaling in lymphocytes are the Tec family kinases TFKs which include Tec Bruton s tyrosine kinase Btk IL-2 inducible T-cell kinase Itk also known as EMT or TSK resting lymphocyte kinase Rlk also known as Txk and Bmx Etk . These kinases are activated by a wide variety of surface receptors including antigen cytokine chemokine G-protein coupled and Toll-like receptors as well as integrins 1 .

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