TAILIEUCHUNG - Báo cáo khoa học: Mechanisms of obesity and related pathologies: The macro- and microcirculation of adipose tissue

Adipose tissue is an endocrine organ made up of adipocytes, various stro-mal cells, resident and infiltrating immune cells, and an extensive endo-thelial network. Adipose secretory products, collectively referred to as adipokines, have been identified as contributors to the negative conse-quences of adipose tissue expansion that include cardiovascular disease, diabetes and cancer. | MINIREVIEW Mechanisms of obesity and related pathologies The macro- and microcirculation of adipose tissue Joseph M. Rutkowski1 Kathryn E. Davis1 and Philipp E. Scherer1 2 1 Touchstone Diabetes Center Department of InternalMedicine University of Texas Southwestern MedicalCenter Dallas TX USA 2 Department of CellBiology University of Texas Southwestern MedicalCenter Dallas TX USA Keywords adipokine adiponectin angiogenesis endothelial cell hypoxia inflammation lymphangiogenesis lymphatic permeability Correspondence P. E. Scherer Touchstone Diabetes Center Department of InternalMedicine University of Texas Southwestern MedicalCenter 5323 Harry Hines Boulevard Dallas TX 75390 8549 USA Fax 1 214 648 8720 Tel 1 214 648 8715 E-mail Received 25 March 2009 revised 4 August 2009 accept 7 August 2009 doi Adipose tissue is an endocrine organ made up of adipocytes various stromal cells resident and infiltrating immune cells and an extensive endothelial network. Adipose secretory products collectively referred to as adipokines have been identified as contributors to the negative consequences of adipose tissue expansion that include cardiovascular disease diabetes and cancer. Systemic blood circulation provides transport capabilities for adipokines and fuels for proper adipose tissue function. Adipose tissue microcirculation is heavily impacted by adipose tissue expansion some adipokines can induce endothelial dysfunction and angiogenesis is necessary to counter hypoxia arising as a result of tissue expansion. Tumors such as invasive lesions in the mammary gland co-opt the adipose tissue microvasculature for local growth and metastatic spread. Lymphatic circulation an area that has received little metabolic attention provides an important route for dietary and peripheral lipid transport. We review adipose circulation as a whole and focus on the established and potential interplay between adipose tissue and the .

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• Adipose tissue is an endocrine organ made up of adipocytes
• various stro mal cells
• resident and infiltrating immune cells
• and an extensive endo thelial network
• Adipose secretory products
• collectively referred to as adipokines
• have been identified as contributors to the negative conse quences of adipose tissue expansion that include cardiovascular disease
• diabetes and cancer
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