TAILIEUCHUNG - Báo cáo khoa học: Epidermal growth factor receptor-regulated miR-125a-5p – a metastatic inhibitor of lung cancer

Both the epidermal growth factor receptor signaling pathway and micro-RNA (miRNA) play an important role in lung cancer development and progression. To address the potential role of miRNA in epidermal growth factor receptor signaling, we identified miR-125a-5p as a downstream target, using an miRNA array. | ỊFEBS Journal Epidermal growth factor receptor-regulated miR-125a-5p - a metastatic inhibitor of lung cancer Guofu Wang1 2 Weimin Mao1 Shu Zheng2 and Jingjia Ye2 1 Department of Respiratory Disease Zhejiang Hospital Hangzhou China 2 College of Life Sciences Zhejiang University Hangzhou China Keywords epidermal growth factor receptor lung neoplasm metastasis microRNA miR-125a Correspondence W. Mao 12 Lingyin Road Hangzhou 310013 China Fax 86 571 87995379 Tel 86 571 87987373 E-mail maowm1218@ S. Zheng 88 Jiefang Road Hangzhou 310006 China Fax 86 571 87214404 Tel 86 571 87783868 E-mail zhengshu@ Re-use of this article is permitted in accordance with the Terms and Conditions set out at http . com authorresources Received 23 April 2009 revised 12 July 2009 accepted 27 July 2009 doi Both the epidermal growth factor receptor signaling pathway and micro-RNA miRNA play an important role in lung cancer development and progression. To address the potential role of miRNA in epidermal growth factor receptor signaling we identified miR-125a-5p as a downstream target using an miRNA array. We further demonstrated that miR-125a-5p inhibited migration and invasion of lung cancer cells. Moreover miR-125a-5p regulated the expression of several downstream genes of epidermal growth factor receptor signaling. Importantly examination of lung cancer samples revealed a significant correlation of miR-125a-5p repression with lung carcinogenesis. Taken together our results provide compelling evidence that miR-125a-5p an epidermal growth factor-signaling-regulated miRNA may function as a metastatic suppressor. Introduction Lung cancer is the most frequent cause of cancer death in the USA with a mortality of approximately 85 for all stages according to population statistics 1 . Furthermore it is the most common cancer both in incidence rate and in death rate in developing countries such as China 2 . Clinical

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