TAILIEUCHUNG - Breath biomarkers of active pulmonary tuberculosis

Volatile organic compounds (VOCs) in breath may contain biomarkers of active pulmonary tuberculosis derived from the infectious organism (metabolites of Mycobacterium tuberculosis) and from the infected host (products of oxidative stress). Methods: We analyzed breath VOCs in 226 symptomatic high-risk patients in USA, Philippines, and UK, using gas chromatography/mass spectroscopy. Diagnosis of disease was based on sputum culture, smear microscopy, chest radiography and clinical suspicion of tuberculosis (CSTB). Chromatograms were converted to a series of 8 s overlapping time slices. Biomarkers of active pulmonary tuberculosis were identified with a Monte Carlo analysis of time-slice alveolar gradients (abundance in breath minus abundance in room air) | ARTICLE IN PRESS Tuberculosis xxx 2010 1-7 Contents lists available at ScienceDirect Tuberculosis journal homepage http journals tube Tuberculosis DIAGNOSTICS Breath biomarkers of active pulmonary tuberculosis Michael Phillipsa b Victoria Basa-Dalayc h Graham Bothamleyd i Renee N. Cataneoa j Phung Kim Lame k Maria Piedad R. Natividad f l Peter Schmittg m James Waia j a Menssana Research Inc. 1 Horizon Road Suite 1415 Fort Lee NJ 07024-6510 United States b Department of Medicine New York Medical College Valhalla NY United States c Tuberculosis Research Unit Angelo King Medical Research Center De La Salle Health Sciences Institute Cavite Philippines d Department of Respiratory Medicine Homerton University Hospital NHS Foundation Trust London E9 6SR England UK e Division of Pulmonary and Critical Care Medicine University of California San Diego 200 West Arbor Drive San Diego CA 92103-8374 USA f Center for Respiratory Medicine The University of Santo Tomas Hospital USTH Espana Boulevard Manila 1008 Philippines g Schmitt Associates 211 Warren St Newark NJ 07103 United States ARTICLE INFO s u M M A R y Article history Received 27 October 2009 Received in revised form 18 January 2010 Accepted 26 January 2010 Keywords Tuberculosis Breath Volatile Biomarker Diagnosis Background Volatile organic compounds VOCs in breath may contain biomarkers of active pulmonary tuberculosis derived from the infectious organism metabolites of Mycobacterium tuberculosis and from the infected host products of oxidative stress . Methods We analyzed breath VOCs in 226 symptomatic high-risk patients in USA Philippines and UK using gas chromatography mass spectroscopy. Diagnosis of disease was based on sputum culture smear microscopy chest radiography and clinical suspicion of tuberculosis CSTB . Chromatograms were converted to a series of 8 s overlapping time slices. Biomarkers of active pulmonary tuberculosis were identified with a Monte Carlo analysis of time-slice .

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