TAILIEUCHUNG - Adjunctive micronutrient supplementation for pulmonary tuberculosis

In many industrialized countries, an increasing proportion of tuberculosis patients are immigrants. Immigrants account for 50% of the incidence in the Netherlands (12). Control policies with regard to immigrant tuberculosis usually rely on chest x-ray screening and treatment of active tuberculosis. A supplemental approach, recommended by the Institute of Medicine (14), is to conduct tuberculin skin testing and to apply preventive treatment of latent infections. Whether all tuberculin skin test–positive immigrants should be treated, or only selected high-risk groups such as immigrants with radiographic evidence of inactive disease, is under debate (15). Adherence to preventive treatment is also a point to consider (15). To answer the question of why the incidence rates remain high,. | ArtÍculo original Adjunctive micronutrient supplementation for pulmonary tuberculosis Rodrigo X Armijos MD ScD l M Margaret Weigel PhD l Rocío Chacon MD I Luis Flores RN DPH 1 2 Armando Campos MD. 2 Armijos RX Weigel MM Chacon R Flores L Campos A. Adjunctive micronutrient supplementation for pulmonary tuberculosis. Salud Publka Mex 2010 52 185-189. Abstract Objective. To assess the effect of micronutrient supplementation on tuberculosis TB patient outcomes. Material and Methods. The randomized double-blinded placebo-controlled study was conducted in pulmonary TB patients undergoing directly observed treatment short course tratamiento acortado estrictamente supervisado TAES DOTS at IMSS in Ciudad Juarez Chihuahua Mexico who were recruited during August 2005-July 2006. Consecutive patients received zinc and vitamin A supplements or matched placebo for four months. Dietary intake blood zinc and vita-minA immune response IFN-Y TNF-a and IL-10 mRNA and sputum smear conversion were measured. proportion of micronutrient compared to placebo group subjects with a negative sputum smear by month 3 was significantly increased p . This occurred subsequent to increased TNF -a and IFN-Y and decreased IL-I0 observed at month 2. Micronutrient supplementation appeared to accelerate the beneficial therapeutic effect of chemotherapy. Conclusions. The earlier elimination of bacilli from sputum was associated with improved zinc status and Thl immune response. The therapeutic effect of vitamin A was less evident. Key words pulmonary tuberculosis zinc vitamin A cytokines Mexico Armijos RX Weigel MM Chacon R Flores L Campos A. Suplementación con micronutrientes como tratamiento adjunto para tuberculosis pulmonar. Salud Publica Mex 2010 52 185-189. Resumen Objetivo. Determinar el efecto de la suplementación con zinc y vitamina A o placebo en pacientes tratados por tuberculosis TB . Material y métodos. Se realizó un ensayo aleatorizado en pacientes tuberculosos que .

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