TAILIEUCHUNG - Health and Quality of Life Outcomes BioMed Central Research Open Access The two-year impact of

Health and Quality of Life Outcomes BioMed Central Research Open Access The two-year impact of first generation protease inhibitor based antiretroviral therapy (PI-ART) on health-related quality of life Lars E Eriksson*1,2,3, Göran A Bratt2, Eric Sandström2 and Gun Nordström1 Address: 1Department of Nursing, Karolinska Institutet, 23300, SE-141 83 Huddinge, Sweden, 2Department of Venhälsan, South Stockholm General Hospital, SE-118 83 Stockholm, Sweden and 3Department of Virology, Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden Email: Lars E Eriksson* - ; Göran A Bratt - ; Eric Sandström - ; Gun Nordström - * Corresponding author Published: 04 May 2005 Health and Quality of Life Outcomes. | BioMed Central Health and Quality of Life Outcomes Research Open Access The two-year impact of first generation protease inhibitor based antiretroviral therapy PI-ART on health-related quality of life Lars E Eriksson 1 2 3 Goran A Bratt2 Eric Sandstrom2 and Gun Nordstrom1 Address Department of Nursing Karolinska Institutet 23300 SE-141 83 Huddinge Sweden 2Department of Venhalsan South Stockholm General Hospital SE-118 83 Stockholm Sweden and 3Department ofVirology Swedish Institute for Infectious Disease Control SE-171 82 Solna Sweden Email Lars E Eriksson - Goran A Bratt - Eric Sandstrom - Gun Nordstrom - Corresponding author Published 04 May 2005 Received 16 December 2004 Health and Quality of Life Outcomes 2005 3 32 doi l477-7525-3- Accepted 04 May 2005 32 This article is available from http content 3 1 32 2005 Eriksson et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Protease inhibitor based antiretroviral therapy PI-ART was introduced in 1996 and has greatly reduced the incidence of HIV-related morbidity and mortality in the industrialised world. PI-ART would thus be expected to have a positive effect on health-related quality of life HRQL . On the other hand HRQL might be negatively affected by strict adherence requirements as well as by short and longterm adverse effects. The aim of this study was to assess the influence of two years of first generation PI-ART on HRQL in patients with a relatively advanced state of HIV-infection. Furthermore we wanted to investigate the relation between developments in HRQL and viral response self-reported adherence and subjective .

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