TAILIEUCHUNG - Effect modification of air pollution on Urinary 8-Hydroxy-2’-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions

Economics: Evaluation of the traffic-related health impacts and their monetarisation: Using epidemiological data regarding the relation between air pollution and morbidity and premature mortality, the number of cases of morbidity and/or premature mortality attributed to air pollution is determined for each of the health outcomes separately, using specific exposure-response functions. The same operations are carried out for the theoretical situation in which there is no road traffic-related air pollution. The difference between the results of these two calculations corresponds to the cases of morbidity and premature mortality due to road traffic-related air pollution. The morbidity and mortality costs arising from road traffic-related air pollution are then evaluated for. | Ren et al. Environmental Health 2010 9 78 http content 9 1 78 ENVIRONMENTAL HEALTH RESEARCH Open Access Effect modification of air pollution on Urinary 8-Hydroxy-2 -Deoxyguanosine by genotypes an application of the multiple testing procedure to identify significant SNP interactions 1 2 1 3 3 1 Cizao Ren Pantel S Vokonas Helen Suh Shona Fang David C Christian Joel Schwartz Abstract Background Air pollution is associated with adverse human health but mechanisms through which pollution exerts effects remain to be clarified. One suggested pathway is that pollution causes oxidative stress. If so oxidative stress-related genotypes may modify the oxidative response defenses to pollution exposure. Methods We explored the potential pathway by examining whether an array of oxidative stress-related genes twenty single nucleotide polymorphisms SNPs in nine genes modified associations of pollutants organic carbon OC ozone and sulfate with urinary 8-hydroxy-2-deoxygunosine 8-OHdG a biomarker of oxidative stress among the 320 aging men. We used a Multiple Testing Procedure in R modified by our team to identify the significance of the candidate genes adjusting for a priori covariates. Results We found that glutathione S-tranferase P1 GSTP1 rs1799811 M1 and catalase rs2284367 and groupspecific component GC rs2282679 rs1155563 significantly or marginally significantly modified effects of OC and or sulfate with larger effects among those carrying the wild type of GSTP1 catalase non-wild type of GC and the non-null of GSTM1. Conclusions Polymorphisms of oxidative stress-related genes modified effects of OC and or sulfate on 8-OHdG suggesting that effects of OC or sulfate on 8-OHdG and other endpoints may be through the oxidative stress pathway. Background Many studies have shown that ambient pollution is consistently associated with adverse health outcomes 1-6 but mechanisms accountable for these associations have not been fully elucidated. Suggested biological .

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