TAILIEUCHUNG - Báo cáo khoa học: "Concurrent radiochemotherapy in advanced hypopharyngeal cancer"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Concurrent radiochemotherapy in advanced hypopharyngeal cancer. | Krstevska et al. Radiation Oncology 2010 5 39 http content 5 1 39 RADIATION ONCOLOGY RESEARCH Open Access Concurrent radiochemotherapy in advanced hypopharyngeal cancer Valentina Krstevska 1 Igor Stojkovski 21 and Dusko LukarskD2 Abstract Background Concurrent platinum-based radiochemotherapy has been recommended as a standard of care in patients with locally advanced squamous cell head and neck carcinomas. Unfortunately there is a lack of level one evidence on best treatment approach for advanced hypopharyngeal cancer. This report aims to summarize the results of our study on concurrent radiochemotherapy in patients with advanced hypopharyngeal cancer. Methods A retrospective analysis of 41 patients with stage III-IV hypopharyngeal cancer was performed. All patients were treated with three dimensional conformal radiotherapy and received 70 Gy in 35 fractions 2 Gy per fraction 5 fractions per week . In dependence of the period when radiotherapy was realized two different treatment techniques were used. Concurrent chemotherapy consisted of cisplatin 30 mg m2 given on a weekly basis. Results The median age was 52 years range 29-70 . Stage IV disease was recognized in of the patients. Complete response rates at the primary site and at the metastatic neck lymph nodes were and respectively. A complete composite response was present in 27 patients . Median follow-up was 13 months range 7-36 . Distant metastases as initial failure occurred in 7 patients . The 2-year local relapse-free survival and regional relapse-free survival rates were and respectively. The 2-year locoregional relapse-free survival rate was . The 2-year disease-free survival and overall survival rates were and respectively. Confluent mucositis was developed in of patients. Leucopenia grade 1 was the most frequent hematological toxicity. The median weight loss at the end of treatment was 12 range 5-21 . The worst grade of late .

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