TAILIEUCHUNG - Báo cáo khoa học: "Recurrence patterns of locally advanced head and neck squamous cell carcinoma after 3D conformal (chemo)-radiotherapy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Recurrence patterns of locally advanced head and neck squamous cell carcinoma after 3D conformal (chemo)-radiotherapy. | Oksuz et al. Radiation Oncology 2011 6 54 http content 6 1 54 RADIATION ONCOLOGY RESEARCH Open Access Recurrence patterns of locally advanced head and neck squamous cell carcinoma after 3D conformal chemo -radiotherapy 1 111 2 3 Didem C Oksuz Robin J Prestwich Brendan Carey Stuart Wilson Mustafa S Senocak Ananya Choudhury Karen Dyker1 Catherine Coyle1 and Mehmet Sen1 Abstract Background To establish recurrence patterns among locally advanced head and neck non-nasopharyngeal squamous cell carcinoma HNSCC patients treated with radical chemo- radiotherapy and to correlate the sites of loco-regional recurrence with radiotherapy doses and target volumes Method 151 locally advanced HNSCC patients were treated between 2004-2005 using radical three-dimensional conformal radiotherapy. Patients with prior surgery to the primary tumour site were excluded. The sites of locoregional relapses were correlated with radiotherapy plans by the radiologist and a planning dosimetrist. Results Median age was 59 years range 34-89 . 35 patients had stage III disease 116 patients had stage IV A B. 36 patients were treated with radiotherapy alone 42 with induction chemotherapy 63 with induction and concomitant chemoradiotherapy and 10 concomitant chemoradiotherapy. Median follow-up was 38 months range 3-62 . 3-year cause specific survival was . 125 of 151 achieved a complete response to treatment. Amongst these 125 there were 20 local-regional recurrence comprising 8 local 5 regional and 7 simultaneous local and regional synchronous distant metastases occurred in 7 of the 20. 9 patients developed distant metastases in the absence of locoregional failure. For the 14 local recurrences with planning data available 12 were in-field 1 was marginal and 1 was out-of-field. Of the 11 regional failures with planning data available 7 were in-field 1 was marginal and 3 were out-of-field recurrences. Conclusion The majority of failures following non-surgical treatment for .

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