TAILIEUCHUNG - Báo cáo khoa học: An ecdysteroid-inducible insulin-like growth factor-like peptide regulates adult development of the silkmoth Bombyx mori

In anautogenous mosquitoes, egg development requires blood feeding and as a consequence mosquitoes act as vectors of numerous devastating dis-eases of humans and domestic animals. Understanding the molecular mechanisms regulating mosquito egg development may contribute signi-ficantly to the development of novel vector-control strategies. | ỊFEBS Journal An ecdysteroid-inducible insulin-like growth factor-like peptide regulates adult development of the silkmoth Bombyx mori Naoki Okamoto1 Naoki Yamanaka2 Honoo Satake3 Hironao Saegusa1 f Hiroshi Kataoka2 and Akira Mizoguchi1 1 Division of BiologicalScience Graduate Schoolof Science Nagoya University Japan 2 Department of Integrated Biosciences Graduate Schoolof Frontier Sciences The University of Tokyo Kashiwanoha Kashiwa Chiba Japan 3 Suntory Institute for Bioorganic Research Osaka Japan Keywords Bombyx mori ecdysteroid fat body insulin-like growth factors IGFs insulin-like peptides Correspondence A. Mizoguchi Division of BiologicalScience Graduate School of Science Nagoya University Furo-cho Chikusa-ku Nagoya 464-8602 Japan Fax 81 52 789 2511 Tel 81 52 789 5039 E-mail mizoguch@ Present address Department of Genetics CellBiology Development University of Minnesota Mineapolis MN USA fDepartment of Pharmacology and Neurobiology Graduate Schoolof Medicine Tokyo Medicaland DentalUniversity Japan Database The sequence reported in this article has been deposited in the GenBank database http Genbank under accession numbers AB360450-AB360454 Insulin-like growth factors IGFs play essential roles in fetal and postnatal growth and development of mammals. They are secreted by a wide variety of tissues with the liver being the major source of circulating IGFs and regulate cell growth differentiation and survival. IGFs share some biological activities with insulin but are secreted in distinct physiological and developmental contexts having specific functions. Although recent analyses of invertebrate genomes have revealed the presence of multiple insulin family peptide genes in each genome little is known about functional diversification of the gene products. Here we show that a novel insulin family peptide of the silkmoth Bombyx mori which was purified and sequenced from the hemolymph is more like IGFs than like insulin in .

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