TAILIEUCHUNG - Báo cáo khoa học: Post-ischemic brain damage: pathophysiology and role of inflammatory mediators

Neuroinflammatory mediators play a crucial role in the pathophysiology of brain ischemia, exerting either deleterious effects on the progression of tis-sue damage or beneficial roles during recovery and repair. Within hours after the ischemic insult, increased levels of cytokines and chemokines enhance the expression of adhesion molecules on cerebral endothelial cells, | ỊFEBS Journal MINIREVIEW Post-ischemic brain damage pathophysiology and role of inflammatory mediators Diana Amantea1 Giuseppe Nappi2 Giorgio Bernardi3 Giacinto Bagetta1 4 and Maria T. Corasaniti5 1 Department of Pharmacobiology University of Calabria Rende CS Italy 2 IRCCS C. Mondino Institute of Neurology Foundation Pavia Italy and Department of ClinicalNeurology and Otorhinolaryngology La Sapienza University Rome Italy 3 IRCCS-Santa Lucia Foundation Centre of Excellence in Brain Research and Department of Neuroscience Tor Vergata University Rome Italy 4 University Centre for Adaptive Disorders and Headache Section of Neuropharmacology of Normaland PathologicalNeuronalPlasticity University of Calabria Rende CS Italy 5 Department of PharmacobiologicalSciences Magna Graecia University Catanzaro Italy and ExperimentalNeuropharmacology Center Mondino-Tor Vergata IRCCS-C. Mondino Foundation Rome Italy Keywords brain ischemia cytokines matrix metalloproteinases microglia neuroinflammation Correspondence D. Amantea Department of Pharmacobiology University of Calabria via P. Bucci Ed. Polifunzionale 87036 Arcavacata di Rende CS Italy Fax 39 0984 493271 Tel 39 0984 493270 E-mail Received 28 June 2008 revised 7 October 2008 accepted 21 October 2008 doi Neuroinflammatory mediators play a crucial role in the pathophysiology of brain ischemia exerting either deleterious effects on the progression of tissue damage or beneficial roles during recovery and repair. Within hours after the ischemic insult increased levels of cytokines and chemokines enhance the expression of adhesion molecules on cerebral endothelial cells facilitating the adhesion and transendothelial migration of circulating neutrophils and monocytes. These cells may accumulate in the capillaries further impairing cerebral blood flow or extravasate into the brain parenchyma. Infiltrating leukocytes as well as resident brain cells including neurons and glia .

• Báo cáo khoa học
• medical reports
• thesis report
• traditional medicine
• intermediate cells
• cell proliferation
• medical analysis
• statements and documents scientific reports
• medical knowledge
• medical research
• clinical trials
• medical management
• health care
• medical transfer
• the developing countries