TAILIEUCHUNG - Cognitive effects of acute tryptophan depletion in the healthy elderly

Gaps in knowledge were detected in the course of this review. These are summarized in the following section, which also suggests directions for further investigation. Further study and regular dietary monitoring are needed in order to know more about food consumption habits in seniors. These investigations must be adapted to the reality of targeted aging populations using precise measurements, diverse approaches, appropriate methods and accurate dietary assessment tools to reflect the great heterogeneity typical of older populations. The research agenda should be focussed on interactions between individual and collective determinants of healthy eating that are unique to the elderly in Canada. To achieve this goal, longitudinal studies should be conducted to examine the epidemiological and social aspects of aging; describe the. | Acta Neuropsychiatrica 2008 20 78-86 AỈỈ rights reserved DOI 2008 The Authors Journal compilation 2008 Blackwell Munksgaard ACTA NEUROPSYCHIATRỈCA Cognitive effects of acute tryptophan depletion in the healthy elderly Mace J Porter R O Brien J Gallagher P. Cognitive effects of acute tryptophan depletion in the healthy elderly. Background Studies investigating the cognitive effects of serotonin depletion using the technique of acute tryptophan depletion ATD by dietary means have generally suggested that ATD impairs delayed verbal recall and recognition. In two previous studies in the elderly this result has not been replicated and ATD impaired working memory. These results may be susceptible to type II error but a similar testing schedule in the individual studies allows data to be pooled in a larger analysis. Methods Data from two separate double-blind placebo-controlled studies of the effects of ATD on cognitive function in the elderly were combined. In one study a low dose and in the other a high dose of amino acids was used. In a repeated measures analysis of variance the effects of ATD and the interaction of this with the other factors age gender and dose on cognitive measures was examined. Results Data from 31 healthy subjects aged between 60 and 81 years were analysed. There were no main effects of ATD or consistent interactions between ATD and age gender or dose. There were significant interactions between ATD gender and dose. When tryptophan depleted females having the higher dose drink had reduced scores on Digit span and immediate recall on the Rey Auditory Verbal Learning Test. Conclusion The enlarged data set did not confirm an overall effect of ATD on working memory or on delayed word recall but does suggest an effect of ATD on encoding or registration in the subgroup of females receiving a higher strength drink. Janet Mace1 Richard Porter1 John O Brien2 Peter Gallagher3 department of Psychological Medicine University .

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