TAILIEUCHUNG - Lipid profile variations in a group of healthy elderly and centenarians

There are a number of well-recognized indicators of biological risk for cardiovascular disease, diabetes, and death for which change over some period of time can be determined from the . National Health and Nutrition Examination Surveys (NHANES). Collection of some measures began as early as the 1960s, and some are not available until the 1980s. NHANES data show that the percentage of the older population with high cholesterol has decreased since the 1960s, somewhat faster for women than men (60). Examination of recent change shows a reduction in average total cholesterol during the 1990s for the older population (Table 2) | European Review for Medical and Pharmacological Sciences 1998 2 75-79 Lipid profile variations in a group of healthy elderly and centenarians M. MALAGUARNERA I. GIUGNO P. RUELLO M. RIZZO . PANEBIANCO G. PISTONE . TOMASELLO Department of Internal Medicine and Geriatrics - University of Catania Italy Abstract. Epidemiological and clinical studies have clearly shown a close relationship between plasma cholesterol concentrations and vascular risk. We focused our attention on the phenotypic-biohumoral conditions capable of influencing longevity in relation to different age classes. We evaluated the lipid profile in an elderly institutionalized population of 80 subjects 20 males and 60 females divided into age classes in the town of Catania. Our results revealed a statistically significant reduction in total cholesterol triglycerides and LDL-cholesterol concentrations as well as Apolipoprotein B100 Apolipoprotein A1 total choles-terol HDL-cholesterol and LDL-cholesterol HDL-cholesterol ratios and a significant increase in HDL-cholesterol Apolipoprotein A1 Apolipoprotein B100 and Lipoprotein a values. This changes are progressiv with age. We believe that low total cholesterol LDL-cholesterol and triglyceride concentrations elevated HDL-cholesterol values and low ratios protect subjects from ischemic and thrombotic events thus favouring longevity. These changes are most evident and statistically significant in the most advanced decades of life especially in centenarians and may depend on diverse determinants such as body composition environmental factors physical activity diet and drugs. Key Words Aging Lipoproteins Lp a Centenarians. Introduction Epidemiological and clinical studies have clearly shown a close relationship between plasma cholesterol concentrations and vascular risk1. Although it is impossible to conduct controlled studies aimed at detecting the genetic factors of longevity the incidence of vascular disease is much lower and onsets lat er in some .

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