TAILIEUCHUNG - Tissue Engineering and Reparative Medicine

The term reparative medicine is often used to denote the replacement, repair, or functional enhancement of tissues and organs. Reparative medicine has traditionally used materials at hand and the technology of the day to restore or improve function of organs and tissues afflicted with birth defects or the ravages of injury, disease, and age. The driving force for reparative medicine has been clinical need; clinicians, par- ticularly surgeons, have recruited practitioners from multiple disciplines to address complex biological problems that are well beyond a single scientific or engineering discipline. Depending upon the particular organ or tissue at stake, a number of re- parative medicine strategies have been employed:. | Tissue Engineering and Reparative Medicine JEAN D. SIPE Center for Scientific Review National Institutes of Health Bethesda Maryland 20814 USA Abstract Reparative medicine is a critical frontier in biomedical and clinical research. The National Institutes of Health Bioengineering Consortium BECON convened a symposium titled Reparative Medicine Growing Tissues and Organs which was held on June 25 and 26 2001 in Bethesda Maryland. The relevant realms of cells molecular signaling extracellular matrix engineering design principles vascular assembly bioreactors storage and translation and host remodeling and the immune response that are essential to tissue engineering were discussed. This overview of the scientific program summarizes the plenary talks extended poster presentations and breakout session reports with an emphasis on scientific and technical hurdles that must be overcome to achieve the promise of restoring replacing or enhancing tissue and organ function that tissue engineering offers. Keywords bioreactors biomaterials bioscaffolds cryopreservation host remodeling INTRODUCTION The term reparative medicine is often used to denote the replacement repair or functional enhancement of tissues and organs. Reparative medicine has traditionally used materials at hand and the technology of the day to restore or improve function of organs and tissues afflicted with birth defects or the ravages of injury disease and age. The driving force for reparative medicine has been clinical need clinicians particularly surgeons have recruited practitioners from multiple disciplines to address complex biological problems that are well beyond a single scientific or engineering discipline. Depending upon the particular organ or tissue at stake a number of reparative medicine strategies have been employed 1 substitution of one body part for another Godbey and Atala report that substitution of one body part for another has been practiced since at least the time of Socrates1 2 repair .

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