TAILIEUCHUNG - Báo cáo khoa học: Crystal structure of a cold-adapted class C b-lactamase

In this study, the crystal structure of a class Cb-lactamase from a psychro-philic organism,Pseudomonas fluorescens, has been refined to A ˚ resolu-tion. It is one of the few solved crystal structures of psychrophilic proteins. The structure was compared with those of homologous mesophilic enzymes and of another, modeled, psychrophilic protein. | ỊFEBS Journal Crystal structure of a cold-adapted class C b-lactamase c athoKi no Ir ha11Y1 1an l laccan 2 PróHórir lốorff3 I oa n - a t i o p ro t o3 loan-Donic rionniiior3 Vduiciii Ic iviiuiidUA f ơai I IVI aoodi IL f neueiiu I ui 11 deal Iiviaiic ricic Jedi IƯCI Ils uuuquici f Icahol 3 nrlon korn Qo m n Pi o f 1 3 rrl3 CẦcm rrt Q Fo 11 o t 3 Pa I I lotto f h a f 11 o t 3 isauei vaiivieiiueiyiie Dail oamyiI MIIIIUK. rieiiaiu Uvuiyvo I e Iiei r auiette kzi I ai Iici Jozef Van Beeumen4 and Johan Wouteis1 1 Chimie Biologique Structurale Laboratory CPTS group FUNDP Namur Belgium 2 Laboratorium voor Erfelijkheidsleer en Microbiologie Vrije Universiteit Brussel Belgium 3 Centre d Ingenierie des Proteines University of Liege Institut de Physique B5 et Institut de Chimie B6a Belgium 4 Laboratory for Protein Biochemistry and Protein Engineering Ghent University Belgium 5 Laboratory of Biochemistry University of Liege Institute of Chemistry B6a Liege-Sart Tilman Belgium Keywords class C b-lactamase cold adaptation psychrophile weak interactions X-ray structure Correspondence C. Michaux Chimie Biologique Structurale Laboratory CPTS group FUNDP 61 rue de Bruxelles B-5000 Namur Belgium Fax 32 81725466 Tel 32 81725457 E-mail Database The protein sequence has been deposited in the UniProt Knowledgebase P85302 with Protein Identification Resource NationalBiomedicalResearch Foundation Georgetown University MedicalCenter Washington DC 20007 The atomic coordinates and structure factors have been deposited in the Protein Data Bank Research Collaboratory for Struc-turalBioinformatics Rutgers University New Brunswick NJ under the code 2QZ6 http Received 17 November 2007 revised 30 January 2008 accepted 6 February 2008 doi In this study the crystal structure of a class C b-lactamase from a psychro-philic organism Pseudomonas fluorescens has been refined to A resolution. It is one of the few solved crystal .

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