TAILIEUCHUNG - Cancer of the Testis

A resolution agreed at ILO’s 2006 conference clarified the purpose of the asbestos convention. It said “the elimination of the future use of asbestos and the identification and proper management of asbestos currently in place are the most effective means to protect workers from asbestos exposure and to prevent future asbestos-related deaths.” The 2006 resolution added that the convention “should not be used to provide a justification for, or endorsement of, the continued use of asbestos.” It instead called for efforts “to promote the elimination of future uses of all forms of asbestos and asbestos containing materials.” ILO’s chemicals convention, C170,. | Chapter 21 Cancer of the Testis Mary L. Biggs and Stephen M. Schwartz INTRODUCTION Testicular cancer is a relatively rare cancer with an estimated 8 250 new cases diagnosed in . men in 2006 1 . Despite the fact that it accounts for only 1 of all malignancies in males it is the most common malignancy in men aged 20-34 and in the . and most western countries the incidence has more than doubled since the 1940s 2 3 . Survival of patients with testicular particularly those with metastatic disease has improved significantly since the early 1970 s as the result of the development and wide-spread use of cisplatin-containing combination chemotherapy. The 5-year survival rate for testicular cancer patients including all stages was 72 in 1970-1973 and 91 for patients diagnosed in 1983-1985 4 . For men diagnosed with testicular cancer during 1992-1998 the 5-yr survival rate was 95 4 and today testicular cancer is considered one of the most curable solid neoplasms 5 . MATERIALS AND METHODS There were 12 978 adult cases of testicular cancer other than testicular lymphomas diagnosed from 1988 through 2001 and reported to the SEER program. A detailed description of the source of these data is given in the introductory chapter of this monograph. Table shows the numbers of cases excluded from the present analysis by reason. This chapter describes survival analysis of the remaining 11 606 histologically confirmed first primary cases of adult testicular cancer diagnosed from 1988 through 2001 and reported to the SEER Program. Histologic Classification Germ cell carcinomas comprise the overwhelming majority of adult testicular carcinomas 6 . Because non-germ cell testis tumors are uncommon and comprise a heterogeneous group the focus of the analysis was on germ cell carcinomas. Within the germ cell neoplasms tumors can be classified based on pathologic and clinical features into two broad histologic groups seminomas and non-seminomas. Seminomas tend to grow more slowly

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