TAILIEUCHUNG - American Society of Clinical Oncology Policy Statement Update: Genetic Testing for Cancer Susceptibility

The Women’s Health Study, which included almost 40,000 healthy women at least 45 years of age, found that vitamin E supplements did not reduce the risk of heart attack, stroke, cancer, age-related macular degeneration, or cataracts. Although vitamin E supplements were associated with fewer deaths from cardiovascular causes, they did not reduce the overall death rate of study participants. The Women’s Antioxidant Cardiovascular Study found no beneficial effects of vitamin C, vitamin E, or beta-carotene supplements on cardiovascular events (heart attack, stroke, or death from cardiovascular diseases) or the likelihood of developing diabetes or cancer in more than 8,000 female. | Published Ahead of Print on April 11 2003 as American Society of Clinical Oncology Policy Statement Update Genetic Testing for Cancer Susceptibility Adopted on March 1 2003 by the American Society of Clinical Oncology Executive Summary As the leading organization representing cancer specialists involved in patient care and clinical research the American Society of Clinical Oncology ASCO reaffirms its commitment to integrating cancer risk assessment and management including molecular analysis of cancer predisposition genes into the practice of oncology and preventive medicine. The primary goal of this effort is to foster expanded access to and continued advances in medical care provided to patients and families affected by hereditary cancer syndromes. The 1996 ASCO Statement on Genetic Testing for Cancer Susceptibility set forth specific recommendations relating to clinical practice research needs educational opportunities requirement for informed consent indications for genetic testing regulation of laboratories and protection from discrimination as well as access to and reimbursement for cancer genetics services. In updating this Statement ASCO endorses the following principles Indications for Genetic Testing ASCO recommends that genetic testing be offered when 1 the individual has personal or family history features suggestive of a genetic cancer susceptibility condition 2 the test can be adequately interpreted and 3 the results will aid in diagnosis or influence the medical or surgical management of the patient or family members at hereditary risk of cancer. ASCO recommends that genetic testing only be done in the setting of pre- and post-test counseling which should include discussion of possible risks and benefts of cancer early detection and prevention modalities. Special Issues in Testing Children for Cancer Susceptibility ASCO recommends that the decision to offer testing to potentially affected children should take into account the

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