TAILIEUCHUNG - Báo cáo khoa học: "Influences of DTC and zinc supplementation on the cellular response restoration in restrained mice"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Influences of DTC and zinc supplementation on the cellular response restoration in restrained mice | J. Vet. Sci. 2005 6 1 25-32 JOURNAL OF Veterinary Science Influences of DTC and zinc supplementation on the cellular response restoration in restrained mice Bozena Obminska-Mrukowicz Marianna Szczypka Department of Biochemistry Pharmacology and Toxicology Faculty of Veterinary Medicine Agricultural University Norwida 31 50-375 Wroclaw Poland The studies were conducted on Balb c mice exposed to restraint stress twice for 12 h at 24 h intervals. Prior to restraint stress the mice were treated with sodium diethyldithiocarbamate DTC . at a dose of 20 mg kg five times at 48 h intervals. DTC was used per se or with zinc ions interaction by adding zinc sulfate to drinking water at a dose of 72 pg mouse daily. The results obtained in the study show that restraint stress causes involution of lymphatic organs decreased the percentage of immature CD4 CD8 and mature CD4 thymocytes and CD4 CD8 and CD19 splenocytes and proliferative response of thymocytes stimulated in vitro with concanavalin A Con A and phytohemagglutinin PHA . The restraint stress decreased also interleukin-1 IL-1 production by murine intraperitoneal macrophages stimulated in vitro with lipopolysaccharide LPS from E. coli. Pretreatment with DTC counteracted restraint stress-induced immunosuppression which is expressed as partial normalisation of the total number of thymocytes splenocytes and IL-1 production accelerated regeneration of thymus and spleen shorter suppressive action of restraint stress on the percentage of CD4 CD8 thymocytes and in total normalisation of the CD4 thymocytes and splenocytes. DTC administered prior to restraint stress augmented the proliferative response of thymocytes to two mitogens. The immunocorrecting action of DTC is enhanced by zinc supplementation expressed in the increased percentage of CD4 thymocytes and splenocytes CD19 splenocytes proliferative activity of thymocytes stimulated with PHA and IL-1 production. The obtained results show that DTC administration can be .

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