TAILIEUCHUNG - Báo cáo khoa hoc:" Alternative models for QTL detection in livestock. II. Likelihood approximations and sire marker genotype estimations"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Alternative models for QTL detection in livestock. II. Likelihood approximations and sire marker genotype estimations | Genet. Sei. Evol. 31 1999 225-237 Inra Elsevier Paris 225 Original article Alternative models for QTL detection in livestock. II. Likelihood approximations and sire marker genotype estimations Brigitte Mangina Bruno Goffineta Pascale Le Royb Didier Boichardb Jean-Michel Eisenc a Biométrie et intelligence artificielle Institut national de la recherche agronomique BP27 31326 Castanet-Tolosan France b Station de génétique quantitative et appliquée Institut national de la recherche agronomique 78352 Jouy-en-Josas France c Station d amelioration génétique des animaux Institut national de la recherche agronomique BP27 31326 Castanet-Tolosan France Received 20 November 1998 accepted 7 April 1999 Abstract - In this paper we compare four different methods of dealing with the unknown linkage phase of sire markers which occurs in the detection of quantitative trait loci QTL in a half-sib family structure when no information is available on grandparents. The methods are compared by considering a Gaussian approximation of the progeny likelihood instead of the mixture likelihood. In the first simulation study the properties of the Gaussian model and of the mixture model were investigated using the simplest method for sire gamete reconstruction. Both models lead to comparable results as regards the test power but the mean square error of sib QTL effect estimates was larger for the Gaussian likelihood than for the mixture likelihood especially for maps with widely spaced markers. The second simulation study revealed that the simplest method for sire marker genotype estimation was as powerful as complicated methods and that the method including all the possible sire marker genotypes was never the most powerful. Inra Elsevier Paris half-sib family QTL detection unknown linkage phase Gaussian approximation log-likelihood ratio test Résumé Modèles alternatifs pour la detection de QTL dans les populations animates. II. Approximations de la vraisemblance et estimations du genotype des .

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