TAILIEUCHUNG - Báo cáo khoa hoc:" The use of molecular markers in conservation programmes of live animals"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: The use of molecular markers in conservation programmes of live animals | 585 Genet. Sei. Evol. 30 1998 585-600 Inra Elsevier Paris Original article The use of molecular markers in conservation programmes of live animals Miguel Toro Luis Silió Jaime Rodriganez Carmen Rodríguez Departamento de Mejora Genética y Biotecnología INIA Ctra. de La Coruna km 7 28040 Madrid Spain Received 6 January 1998 accepted 11 September 1998 Abstract Monte Carlo simulation has been carried out to study the benefits of using molecular markers in a conservation programme to minimize the homozygosity by descent in the overall genome. Selection of the breeding individuals was either at random or based on two alternative criteria overall heterozygosity of the markers or frequency-dependent selection. Even molecular information was available for all the 1 900 simulated loci a conventional tactic such as restriction in the variance of the family size is the most important strategy for maintaining genetic variability. In this context a frequency-dependent selection seems to be a more efficient criterion than selection for heterozygosity and b the value of marker information increases as the selection intensity increases. Results from more realistic cases 1 2 3 4 6 or 10 markers per chromosome and 2 4 6 or 10 alleles per marker confirm the above conclusions. This is an expensive strategy with respect to the number of candidates and the number of markers required in order to obtain substantial benefits the usefulness of a marker being related to the number of alleles. The minimum coancestry mating system was also compared with random mating and it is concluded that it is advantageous at least for many generations. Inra Elsevier Paris molecular markers conservation genetics frequency-dependent selection minimum coancestry mating Resume utilisation de marqueurs moléculaires dans les programmes de conservation des animaux. Des simulations Monte Carlo ont été effectuees pour étudier 1 intérêt de 1 utilisation des marqueurs moléculaires dans un programme de conservation .

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