TAILIEUCHUNG - World Gastroenterology Organisation/International Digestive Cancer Alliance Practice Guidelines: Colorectal cancer screening

The body is made up of trillions of living cells. Normal body cells grow, divide, and die in an orderly way. During the early years of a person's life, normal cells divide faster to allow the person to grow. After the person becomes an adult, most cells divide only to replace worn-out, damaged, or dying cells. Cancer begins when cells in a part of the body start to grow out of control. There are many kinds of cancer, but they all start because of this out-of-control growth of abnormal cells. Cancer cell growth is different from normal cell growth. Instead. | Colorectal cancer screening World Gastroenterology Organisation International Digestive Cancer Alliance Practice Guidelines Colorectal cancer screening Review team Prof. S. Winawer chair USA Prof. M. Classen co-chair Germany Prof. R. Lambert co-chair France Prof. M. Fried Switzerland Prof. P. Dite Czech Republic Prof. . Goh Malaysia Prof. F. Guarner Spain Prof. D. Lieberman USA Prof. R. Eliakim Israel Prof. B. Levin USA Prof. R. Saenz Chile Prof. . Khan Pakistan Prof. I. Khalif Russia Prof. A. Lanas Spain Prof. G. Lindberg Sweden Prof. . O Brien USA Prof. G. Young Australia Dr. J. Krabshuis France International consultants Prof. R. Smith USA Prof. W. Schmiegel Germany Prof. D. Rex USA Prof. N. Amrani Morocco Prof. A. Zauber USA World Gastroenterology Organisation 2007 Colorectal cancer screening Contents 1 Introduction 2 Methodology and literature review 3 Epidemiology of colorectal cancer 4 Screening tests and evidence 1 stool tests occult blood and DNA 5 Screening tests and evidence 2 endoscopy and CT colonography 6 Cost-effectiveness of CRC screening 7 Cascades - tooling up for screening 8 Where to get help 9 Useful web sites guidelines and selected references 10 Queries and feedback 1 Introduction Colorectal cancer CRC is a worldwide problem with an annual incidence of approximately 1 million cases and an annual mortality of more than 500 000. The absolute number of cases will increase over the next two decades as a result of the aging and expansion of populations in both the developed and developing countries. CRC is the second most common cause of cancer mortality among men and women. Most CRCs arise from sporadic adenomas and a few from genetic polyposis syndromes or inflammatory bowel disease IBD . The term polyp refers to a discrete mass that protrudes into the intestinal lumen. The reported prevalence of adenomatous polyps on the basis of screening colonoscopy data is in the range of 18-36 . The risk for CRC varies from country to country and .

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