TAILIEUCHUNG - Báo cáo khoa học: Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide – interference with interferon-c-STAT1-mediated killing

The signal transducers and activators of transcription (STATs) convey sig-nals from the membrane to the nucleus in response to cytokines or growth factors. STAT3 is activated in response to cytokines involved mostly in cell proliferation; STAT1 is activated by cytokines, including interferon-c, involved in defence against pathogens and the inhibition of cell prolifera-tion. | ỊFEBS Journal Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription STAT 3 hairpin decoy oligodeoxynucleotide - interference with interferon-y-STAT1-mediated killing Ạ 11 Tarllaniii I I Ki Ki1 2 f K rĩc ol Io I an IIII líot 1 2 I nòc I licci1 2 Hon ỈQ I ocano1 2 Qtónhanio I o f nniiil1 2 aaou I loLcc aguei I ICO uuuioo cl Ils coayc - te pane e oqu An Cao3 Valeri Metelev4 Fanny Baran-Marszak1 2 5 and Remi Fagard1 2 6 1 Institut Nationalde la Sante et de la Recherche Medicale U978 Bobigny France 2 Universite Paris 13 UFR SMBH Bobigny France 3 Centre Nationalde la Recherche Scientifique UMR 7033 Bobigny France 4 Department of Chemistry Moscow State University Russia 5 AP-HP hopitalAvicenne service d hematologie Bobigny France 6 AP-HP hopitalAvicenne service de biochimie Bobigny France Keywords cell death hairpin decoy oligonucleotide interferon-c STAT1 STAT3 Correspondence R. Fagard service de biochimie hopital Avicenne 125 rue de Stalingrad 93009 Bobigny Cedex France Fax 33 014 895 5627 Tel 33 014 895 5928 E-mail Received 17 November 2008 revised 25 January 2009 accepted 19 February 2009 doi The signal transducers and activators of transcription STATs convey signals from the membrane to the nucleus in response to cytokines or growth factors. STAT3 is activated in response to cytokines involved mostly in cell proliferation STAT1 is activated by cytokines including interferon-y involved in defence against pathogens and the inhibition of cell proliferation. STAT3 which is frequently activated in tumour cells is a valuable target with respect to achieving inhibition of tumour cell proliferation. Indeed its inhibition results in cell death. We previously observed that inhibition of the transcription factor nuclear factor-KB a key regulator of cell proliferation with decoy oligodeoxynucleotides results in cell death. We used a similar approach for STAT3. A hairpin .

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