TAILIEUCHUNG - Báo cáo sinh học: "Comparative analysis of HIV-1-based lentiviral vectors bearing lyssavirus glycoproteins for neuronal gene transfer"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Comparative analysis of HIV-1-based lentiviral vectors bearing lyssavirus glycoproteins for neuronal gene transfer | Genetic Vaccines and Therapy BioMed Central Open Access Comparative analysis of HIV-l-based lentiviral vectors bearing lyssavirus glycoproteins for neuronal gene transfer Thais Federici 1 Robert Kutner2 Xian-Yang Zhang2 Hitoshi Kuroda2 Noel Tordo3 Nicholas M Boulis1 and Jakob Reiser2 4 Address Department of Neurosurgery Emory University Atlanta GA USA 2Gene Therapy Program Louisiana State University Health Sciences Center New Orleans LA USA 3Unit Antiviral Strategies CNRS-URA 3015 Institut Pasteur Paris France and . Food and Drug Administration Center for Biologics Evaluation and Research Division of Cellular and Gene Therapies Bethesda MD USA Email Thais Federici - tfederi@ Robert Kutner - rkutne@ Xian-Yang Zhang - xzhang@ Hitoshi Kuroda - hito@ Noel Tordo - ntordo@ Nicholas M Boulis - nboulis@ Jakob Reiser - Corresponding author Published 13 January 2009 Received 8 October 2008 T rr I Accepted 13 January 2009 Genetic Vaccines and Therapy 2009 7 1 doi 186 1479-0556-7-1 This article is available from http content 7 1 1 2009 Federici et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The delivery of therapeutic genes to the central nervous system CNS using viral vectors represents an appealing strategy for the treatment of nerve injury and disorders of the CNS. Important factors determining CNS targeting include tropism of the viral vectors and retrograde transport of the vector particles. Retrograde transport of equine anemia virus EIAV -based lentiviral vectors pseudotyped with the glycoprotein derived from the Rabies virus RabERA strain from peripheral muscle to spinal motor neurons MNs was

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