TAILIEUCHUNG - Báo cáo sinh học: "Is gene therapy a good therapeutic approach for HIV-positive patients?"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Is gene therapy a good therapeutic approach for HIV-positive patients? | Genetic Vaccines and Therapy BioMed Central Open Access Review Is gene therapy a good therapeutic approach for HIV-positive patients Jai G Marathe1 and Dawn P Wooley 1 2 Address Department of Neuroscience Cell Biology and Physiology Wright State University Dayton OH 45435 USA and 2Center for Retrovirus Research The Ohio State University Columbus OH 43210 USA Email Jai G Marathe - Dawn P Wooley - Corresponding author Published 14 February 2007 Received 9 October 2006 J nrr r r Accepted 14 February 2007 Genetic Vaccines and Therapy 2007 5 5 doi l479-0556-5-5 This article is available from http content 5 1 5 2007 Marathe and Wooley licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Despite advances and options available in gene therapy for HIV- 1 infection its application in the clinical setting has been challenging. Although published data from HIV-1 clinical trials show safety and proof of principle for gene therapy positive clinical outcomes for infected patients have yet to be demonstrated. The cause for this slow progress may arise from the fact that HIV is a complex multi-organ system infection. There is uncertainty regarding the types of cells to target by gene therapy and there are issues regarding insufficient transduction of cells and long-term expression. This paper discusses state-of-the-art molecular approaches against HIV-1 and the application of these treatments in current and ongoing clinical trials. Background In 1983 a new virus was first isolated and associated with acquired immune deficiency syndrome AIDS 1 . Subsequently scientists classified it

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