TAILIEUCHUNG - Báo cáo sinh học: " Coordinated gene expression by post-transcriptional regulons in African trypanosomes"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Coordinated gene expression by post-transcriptional regulons in African trypanosomes. | Journal of Biology Minireview Coordinated gene expression by post-transcriptional regulons in African trypanosomes Marc Ouellette and Barbara Papadopoulou Addresses Centre de Recherche en Infectiologie and Departement de Microbiologie-Infectiologie et Immunologie Université Laval Quebec G1V 4G2 Canada. Correspondence Marc Ouellette. Email . Barbara Papadopoulou. Email . Abstract The regulation of gene expression in trypanosomes is unique. In the absence of transcriptional control at the level of initiation a subset of Trypanosoma brucei genes form post-transcriptional regulons in which mRNAs are co-regulated in response to differentiation signals. See research articles http 1471-2164 10 427 http 1471-2164 10 482 and http 1471-2164 10 495. The kinetoplastid parasites diverged early in the eukaryotic branch of life and several of their members are responsible for some of the great scourges of humanity including sleeping sickness caused by Trypanosoma brucei Chagas disease caused by Trypanosoma cruzi and leishmaniasis caused by Leishmania species . These parasites are distinguished by the kinetoplast the dense DNA-containing region inside the single large mitochondrion. Because of their medical and veterinary importance these parasites have been intensively investigated and their study has led to the discovery of a number of novel basic mechanisms including trans-splicing RNA editing glycosylphospha-tidylinositol-anchoring of membrane proteins and the polarization of T-cell subsets in immunology. The regulation of gene expression in these early-diverging eukaryotes displays some unique features. The findings of three papers published recently in BMC Genomics 1-3 show that despite a lack of transcriptional control at the level of initiation the expression of subsets of genes in T. brucei is regulated during differentiation in a .

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