TAILIEUCHUNG - Báo cáo sinh học: "Genome of a songbird unveiled"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Genome of a songbird unveiled. | Pinaud Journal of Biology 2010 9 19 http content 9 3 19 Journal of Biology MINIREVIEW L__ Genome of a songbird unveiled Raphael Pinaud See research articles http 1471-2164 9 131 http 1471-2164 11 220 http 1471-2202 11 46 and http 1741-7007 8 28 Abstract An international collaborative effort has recently uncovered the genome of the zebra finch a songbird model that has provided unique insights into an array of biological phenomena. The study of songbirds has revealed a variety of fundamental properties of biological systems. In particular neurobiological studies carried out in songbirds have revealed the presence of newly born neurons in the adult brain how steroid hormones affect brain development the neural and mechanistic bases of vocalizations and how experience modifies neuronal physiology. More evidently however songbirds have been extensively used as a model for imitative vocal learning a behavior thought to be a substrate for speech acquisition in humans 1 2 . Now an international consortium has unveiled the genome of the zebra finch Taeniopygia guttata Figure 1 along with a multi-layered analysis of its sequence 3 . Sequencing the zebra finch genome was initiated in 2005 under the Large Scale Genome Sequencing Program of the National Human Genome Research Institute 4 leveraging prior work in the research community characterizing the zebra finch brain transcriptome 5-7 . These initiatives along with new zebra finch genome sequences have resulted in the complete genome sequenced with 17 475 protein-coding genes identified as well as regulatory regions and non-coding RNAs. The annotation and sequence coverage of the zebra finch genome will certainly be refined in the years to come but the initial endeavor is expected to provide a unique platform for modern genomics research in this organism. Furthermore this initial snapshot of the songbird genome should

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