TAILIEUCHUNG - Báo cáo khoa học: Cadmium – glutathione solution structures provide new insights into heavy metal detoxification

Cadmium is a heavy metal and a pollutant that can be found in large quantities in the environment from industrial waste. Its toxicity for living organisms could arise from its ability to alter thiol-containing cellular com-ponents. Glutathione is an abundant tripeptide (c-Glu-Cys-Gly) that is described as the first line of defence against cadmium in many cell types. | 1FEBS Journal Cadmium - glutathione solution structures provide new insights into heavy metal detoxification Olivier Delalande1 z Herve Desvaux2 Emmanuel Godat1 3 Alain Valleix4 Christophe Junot3 Jean Labarre1 and Yves Boulard1 1 Laboratoire de Biologie Intégrative Service de Biologie Integrative et Genetique Moléculaire Institut de Biologie et de Technologies de Saclay CEA-Saclay Gif-sur-Yvette Cedex France 2 Laboratoire Structure et Dynamique par Resonance Magnetique Service de Chimie Moleculaire URA CEA-CNRS 331 IRAMIS CEA-Saclay Gif-sur-Yvette Cedex France 3 Laboratoire d Etude du Metabolisme des Medicaments Service de Pharmacologie et d Immuno Analyse Moleculaire Institut de Biologie et de Technologies de Saclay CEA-Saclay Gif-sur-Yvette Cedex France 4 Service de Chimie Bioorganique et de Marquage Institut de Biologie et de Technologies de Saclay CEA-Saclay Gif-sur-Yvette Cedex France Keywords cadmium chelation glutathione heavy metal toxicity NMR yeast Correspondence Y. Boulard CEA - Direction des Sciences du Vivant Institut de Biologie et de Technologies de Saclay Service de Biologie Integrative et Genetique Moleculaire 91101 Gif-sur-Yvette Cedex France Fax 33 1 69084712 Tel 33 1 69083584 E-mail Present address Centre de Biophysique Moleculaire CNRS UPR 4301 Rue Charles Sadron 45071 Orleans Cedex 2 France Received 12 July 2010 revised 6 October 2010 accepted 12 October 2010 doi Cadmium is a heavy metal and a pollutant that can be found in large quantities in the environment from industrial waste. Its toxicity for living organisms could arise from its ability to alter thiol-containing cellular components. Glutathione is an abundant tripeptide y-Glu-Cys-Gly that is described as the first line of defence against cadmium in many cell types. NMR experiments for structure and dynamics determination molecular simulations competition reactions for metal chelation by different metabolites y-Glu-Cys-Gly .

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