TAILIEUCHUNG - Báo cáo sinh học: " Effects of the number of markers per haplotype and clustering of haplotypes on the accuracy of QTL mapping and prediction of genomic breeding values"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học quốc tế đề tài: Effects of the number of markers per haplotype and clustering of haplotypes on the accuracy of QTL mapping and prediction of genomic breeding values | Genetics Selection Evolution BioMed Central Open Access Effects of the number of markers per haplotype and clustering of haplotypes on the accuracy of QTL mapping and prediction of genomic breeding values Mario PL Calus 1 Theo HE Meuwissen2 Jack J Windig1 Egbert F Knol3 Chris Schrooten4 Addie LJ Vereijken5 and Roel F Veerkamp1 Address 1Animal Breeding and Genomics Centre Animal Sciences Group Wageningen University and Research Centre . Box 65 8200 AB Lelystad The Netherlands 2University of Life Sciences Department of Animal and Aquacultural Sciences As Norway 3IPG Beuningen The Netherlands 4CRV Arnhem The Netherlands and 5Hendrix Genetics . Boxmeer The Netherlands Email Mario PL Calus - Theo HE Meuwissen - Jack J Windig - Egbert F Knol - Chris Schrooten - Addie LJ Vereijken - Roel F Veerkamp - Corresponding author Published 15 January 2009 Received 17 December 2008 Genetics Selection Evolution 2009 41 11 doi 1297-9686-41-11 Accepted 15 January 2009 This article is available from http content 41 1 1 1 2009 Calus et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The aim of this paper was to compare the effect of haplotype definition on the precision of QTL-mapping and on the accuracy of predicted genomic breeding values. In a multiple QTL model using identity-by-descent IBD probabilities between haplotypes various haplotype definitions were tested . including 2 6 12 or 20 marker alleles and clustering base haplotypes related with an IBD probability of or . Simulated data contained 1100 animals with .

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