TAILIEUCHUNG - Báo cáo khoa học: Differential expression of liver and kidney proteins in a mouse model for primary hyperoxaluria type I

Mutations in the alanine-glyoxylate aminotransferase gene (AGXT) are responsible for primary hyperoxaluria type I, a rare disease characterized by excessive hepatic oxalate production that leads to renal failure. A deeper understanding of the changes in the metabolic pathways secondary to the lack of AGXT expression is needed in order to explore substrate depletion as a therapeutic strategy to limit oxalate production in primary hyperoxal-uria type I. | Differential expression of liver and kidney proteins in a mouse model for primary hyperoxaluria type I Juan R. Hernandez-Fernaud1 and Eduardo Salido2 1 Max Planck Institute for Biochemistry Department of Proteomics and SignalTransduction Klopferspitz Martinsried Germany 2 HospitalUniversitario Canarias Center BiomedicalResearch on Rare Diseases CIBERER and Institute of BiomedicalTechnologies ITB Tenerife Spain Keywords hyperoxaluria kidney liver mouse model subcellular fractions Correspondence E. C. Salido HospitalUniversitario Canarias Center Biomedical Research on Rare Diseases CIBERER and Institute of BiomedicalTechnologies ITB Tenerife 38320 Spain Fax 34 922 647 112 Tel 34 922 319 338 E-mail esalido@ Received 29 July 2010 revised 3 September 2010 accepted 10 September 2010 Mutations in the alanine-glyoxylate aminotransferase gene AGXT are responsible for primary hyperoxaluria type I a rare disease characterized by excessive hepatic oxalate production that leads to renal failure. A deeper understanding of the changes in the metabolic pathways secondary to the lack of AGXT expression is needed in order to explore substrate depletion as a therapeutic strategy to limit oxalate production in primary hyperoxaluria type I. We have developed an Agxt knockout AgxtKO mouse that reproduces some key features of primary hyperoxaluria type I. To improve our understanding of the metabolic adjustments subsequent to AGXT deficiency we performed a proteomic analysis of the changes in expression levels of various subcellular fractions of liver and kidney metabolism linked to the lack of AGXT. In this article we report specific changes in the liver and kidney proteome of AgxtKO mice that point to significant variations in gluconeogenesis glycolysis and fatty acid pathways. doi Introduction Primary hyperoxaluria type I PHI is a rare autosomal recessive disease caused by mutations in the alanine-gly-oxylate aminotransferase gene AGXT . .

• Báo cáo khoa học
• Scientific reports
• scientific research
• biochemistry
• Structural biochemistry
• oxidation
• bacteria
• collection of scientific reports
• industry reports philosophy of history reports
• reports in literature
• a scientific b shirt
• presentation of scientific reports
• reports on literature
• philosophy statement
• documents
• studies English language and English language communication and English language commercial
• progress reports at scientific collections
• agronomic reports
• reports in physics
• biology reports
• thematic biological
• induced geometry
• mathematical topics
• quantum mechanics
• physics
• reporting mathematics
• physics reports
• livestock reports
• physical reports
• research physicist
• specializing in physics
• mathematical statements
• mathematical equations
• English pronunciation
• presentation report
• agricultural reports
• technical crops
• bio technology
• English reports
• presentation reports
• mathematical knowledge
• reports of mathematics
• represented
• Wilf on packing distinct
• Tur´n density
• mathematical works
• patterns in a permutation
• statements and documents scientific reports
• reports agronomy
• biotechnology
• plants Vietnam
• specialized biological
• microbiological methods
• presenting the report
• anti bacterial properties of shrimp
• energy exchange
• engineering chicken
• Path counting
• random matrix theory
• Even circuits
• prescribed clockwise parity
• Correspondence between
• algorithmic characterizations
• Finding Induced Acyclic
• Random Digraphs
• Nonexistence results
• Hadamard like matrices
• Voltage Graphs
• Group Presentations
• Cages mathematical knowledge
• Dominance Order
• Graphical Partitions
• On the functions
• values in [α(G
• Box With Translates
• Two Given Rectangular Brick
• On the q analogue
• the sum of cubes